Exercise Rescues Blood-Brain Barrier Structural Impairment and Enhances Mitochondrial Biogenesis in a Hypertensive Mouse Model.

Purpose. Blood-brain barrier (BBB) dysfunction is implicated in various neurodegenerative diseases, including Alzheimer's disease and frontotemporal dementia. Over the past decades, numerous studies have suggested that exercise can mitigate neurodegenerative processes by improving mitochondrial function.