Publications by authors named "Wan-Bei Guo"
Background And Objectives: The effective use of MSCs for the treatment of some B cell-mediated immune diseases is quite limited. The main reason is that the immunomodulatory effects of mesenchymal stem cells (MSCs) on B cells are unclear, and their underlying mechanisms have not been fully explored.
Methods And Results: By co-culturing B cells with MSCs without (MSC/CTLsh) or with suppressor of cytokine signaling 1 (SOCS1) knockdown (MSC/SOCS1sh), we found that MSCs inhibited B cell proliferation, activation and terminal differentiation.
Article Synopsis
- The study investigated how puerarin affects vascular endothelial cell injury caused by lipopolysaccharide (LPS), focusing on the mechanisms behind this effect.
- Using various assays, the researchers evaluated cell viability, morphological changes, and levels of inflammatory markers in cell culture supernatants.
- The results showed that puerarin treatment reduced the harmful effects of LPS on endothelial cells by lowering inflammatory marker levels and inhibiting the activation of NF-κB, which is associated with inflammation.
[Analysis on mutations of GJB2 gene in Chinese population].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
October 2003
Objective: To determine the prevalence and types of GJB2 mutations and to investigate the genetic mechanism in Chinese autosomal recessive deafness.
Methods: The subjects were four Chinese pedigrees (39 individuals) and 50 normal adults. GJB2 was amplified by PCR.