Publications by authors named "Wan Yus Haniff Wan Isa"
Article Synopsis
- Monoclonal antibodies produced using phage display can sometimes have low affinity, making them less useful for applications.
- To improve their effectiveness, a process called affinity maturation is used, which mimics the natural selection process that occurs in the immune system.
- This review will explore different strategies for affinity maturation, focusing on various laboratory techniques, including random mutagenesis, site-directed mutagenesis, and gene synthesis.
Article Synopsis
- * Antibody phage display is a key technique for isolating human monoclonal antibodies, utilizing bacteriophage to present antibody fragments linked to their genes.
- * This method enables a selection process that enriches specific binders and allows for further engineering, making it essential for developing and modifying antibodies.
Background: Differential polarization of macrophage into M1 and M2 mediates atherosclerotic plaque clearance through efferocytosis. Higher expression of Mer proto-oncogene tyrosine kinase (MerTK) on M2 macrophage helps in maintaining macrophage efferocytic efficiency. In healthy individuals, macrophage polarization into M1 and M2 occurs in tissues in concomitance with the acquisition of functional phenotypes depending on specific microenvironment stimuli.
View Article and Find Full Text PDFWe report a case of renal tubular acidosis (RTA) in a patient with HIV infection and AIDS. A 33-year-old HIV-positive man with Hepatitis C and tuberculous lymphadenitis was admitted due to deep venous thrombosis and generalized muscle weakness. He had never received anti-retroviral medication.
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