An Observational Clinical Trial Examining the Effect of Topical Oxygen Therapy (Natrox) on the Rates of Healing of Chronic DiAbetic Foot Ulcers (OTONAL Trial).

Natrox topical oxygen therapy (TOT) (, Cambridgeshire, UK) employs a small battery-powered "oxygen generator" to concentrate atmospheric oxygen and feeds pure, moist, oxygen through a fine, soft tube to a dressing-like "oxygen distribution system", which is placed over the wound and is held in place by a conventional dressing. The aim was to determine the effectiveness of Natrox for non-healing diabetic foot ulcers (DFU) over a 3-month period.Longitudinal, single-arm, open prospective registry study using 12 weeks of TOT using a 4 week run-in period.