Publications by authors named "Wan Qun Xie"
Introduction: Angiotensin-converting enzyme 2 (ACE2) is the receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The effects of SARS-CoV-2 on normal pituitary glands function or pituitary neuroendocrine tumors (PitNETs) have not yet been elucidated. Thus, the present study aimed to investigate the potential risks of SARS-CoV-2 infection on the impairment of pituitary glands and the development of PitNETs.
View Article and Find Full Text PDFThe KBTBD6/7-DRD2 axis regulates pituitary adenoma sensitivity to dopamine agonist treatment.
Acta Neuropathol
September 2020
Article Synopsis
- Pituitary adenomas (PAs) are common brain tumors, with prolactinomas making up about 40% of cases.
- Dopamine agonists like cabergoline are effective treatments for these tumors, but the regulation of the dopamine receptor DRD2, essential for treatment efficacy, is not fully understood.
- This study identifies KBTBD7 as a protein that interacts with and promotes the degradation of DRD2, impacting the sensitivity of pituitary tumors to dopamine agonists and suggesting KBTBD6/7 as a potential therapeutic target.
Exosome-Transmitted lncRNA H19 Inhibits the Growth of Pituitary Adenoma.
J Clin Endocrinol Metab
December 2019
Context: Our previous study demonstrated that the expression of long noncoding RNA (lncRNA) H19 was frequently downregulated in human primary pituitary adenomas and negatively correlated with tumor progression. However, the role of exosomal lncRNA H19 in the inhibition of pituitary tumor growth remains unclear.
Objective: To investigate whether exosomal H19 could be transported across the cell membrane to exert its inhibitory effect on pituitary tumor growth.