OTUB1 promotes the progression of acute myeloid leukemia by regulating glycolysis via deubiquitinating c-Myc.

Acute myeloid leukemia (AML) is the most common type of adult leukemia and patients with AML often have poor prognosis, for which there remains an urgent need to identify novel selective targeted therapy. OTUB1, a deubiquitinating enzyme, is associated with the malignant progression of multiple cancers. However, the role of OTUB1 in AML is still unclear and warrants further investigations.

In vitro and in vivo antibacterial activity, resistance analysis and molecular docking study of pleuromutilin derivatives against Streptococcus suis.

Objectives: To evaluate the in vitro and in vivo antimicrobial activity of pleuromutilin derivatives modified with C14 side-chain against Streptococcus suis.

Methods: To determine the minimum inhibitory concentrations (MICs) of 268 pleuromutilin derivatives with C14 side-chain modifications against S. suis ATCC 43 765 using the broth dilution method.

Compound cancer with small cell carcinoma and mucinous adenocarcinoma of the ovary: a case report and literature review.

Primary small cell carcinoma of the ovary is an extremely rare and highly malignant ovarian malignancy. The tissue origin of this type of cancer is still unclear, and it is characterized by rapid progression and a discouraging prognosis. The clinical presentation of small cell carcinoma of the ovary lacks specificity, and there are currently no effective treatment options available.

Associations of prenatal exposure to fine particulate matter and its constituents with small for gestational age risk: A twin study in China.

This study aimed to examine the impact of PM and its constituents on small for gestational age (SGA). We collected records of 8082 twin pairs and their mothers from 21 hospitals across China. Concentrations of PM and its constituents were from the Tracking Air Pollution dataset.

Polarization-sensitive, self-powered photodetector based on a SnO/MoS van der Waals heterojunction.

Polarization-sensitive ultraviolet photodetectors have a wide range of applications in remote sensing, analytical imaging, information encryption, and anti-counterfeiting. Herein, one-dimensional tin dioxide (SnO) single crystals by using the chemical vapor deposition (CVD) method are reported. The high in-plane anisotropic structure, phonon vibrations, and refractive index of the SnO crystals are experimentally elucidated.

Characteristics and Mechanism of Ammonia Nitrogen Removal by Heterotrophic Nitrification Bacterium LCU1 and Its Application in Wastewater Treatment.

In this study, a novel strain exhibiting heterotrophic nitrification was screened; subsequently, the strain was identified as LCU1 using 16S rRNA gene sequencing. The aim of the study was to investigate the effects of external factors on the NH-N removal efficiency of strain LCU1 in order to elucidate the optimal conditions for NH-N removal by the strain and improve the removal efficiency. The findings indicated that the NH-N removal efficiency of the strain exceeded 80% under optimal conditions (sodium succinate carbon source, C/N ratio of 10, initial pH of 8.

Programmed cell death 1 inhibitor sintilimab plus S-1 and gemcitabine for liver metastatic pancreatic ductal adenocarcinoma.

Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with poor prognosis. When it metastasizes to the liver, treatment options become particularly limited and challenging. Current treatment options for liver metastatic PDAC are limited, and chemotherapy alone often proves insufficient.

The prognostic value of left ventricular diastolic dyssynchrony combined with myocardial perfusion, systolic dyssynchrony, and cardiovascular risk factors in patients with normal left ventricular ejection fraction.

Objective: Major adverse cardiovascular events (MACE) still occur in the normal left ventricular ejection fraction (LVEF) patients with coronary artery disease (CAD). Currently, there are no studies related to the prognostic value of left ventricular diastolic dyssynchrony (LVDD) in combination with perfusion, systolic dyssynchrony, and cardiovascular risk factors in patients with normal LVEF. Therefore, we aimed to investigate the incremental prognostic value of LVDD in patients with normal LVEF and to establish a model to predict MACE.

A hierarchically porous CoS-NiS heterojunction for high-performance lithium sulfur batteries.

The commercial development of lithium-sulfur batteries (LSBs) has been significantly hindered by the "shuttle effect" and the slow redox kinetics of lithium polysulfides (LiPSs). To solve these problems, researchers have designed a variety of catalysts for the conversion of LiPSs. However, the multi-step lithium polysulfide conversion process is difficult to be effectively solved by a single-function catalyst.

Super-enhancer-driven EFNA1 fuels tumor progression in cervical cancer via the FOSL2-Src/AKT/STAT3 axis.

Super-enhancers (SEs) are expansive cis-regulatory elements known for amplifying oncogene expression across various cancers. However, their role in cervical cancer (CC), a remarkable global malignancy affecting women, remains underexplored. Here we applied integrated epigenomic and transcriptomic profiling to delineate the distinct SE landscape in CC by analyzing paired tumor and normal tissues.

Effects of Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Triterpene on Motor and Spatial Learning Disorders in 5xFAD Mice.

Alzheimer's disease (AD) is a prevalent neurodegenerative disorder that gradually destroys cognitive, memory, and thinking skills. Although increasing evidence has demonstrated that Ganoderma lucidum triterpenoids (GLT) can ameliorate the motor and spatial learning disorders of AD, the underlying mechanism remains unclear. Hence, in this study, GLT were obtained by using a traditional Chinese medicine processing method, and then the effects of GLT on motor and spatial learning disorders in 5xFAD mice were investigated by using various techniques such as behavioral analysis, micro-dialysis, and neurophysiological recording.

NACC1 accelerates the progression of AML by regulating the ADAM9/PI3K/AKT axis.

Nucleus accumbens-associated protein 1 (NACC1) regulates various types of biological processes. It is a transcription factor associated with cancer. NACC1 is overexpressed in many human malignancies and can regulate the progression, metastasis, and drug resistance of cancer cells.

Genetic variation in patent foramen ovale: a case-control genome-wide association study.

Background: Patent foramen ovale (PFO) is a congenital defect between the atria, resulting in abnormal hemodynamics. We conducted a genome-wide association study (GWAS) to identify common genetic variants associated with PFO.

Methods: We performed a whole genome sequencing in a discovery cohort of 3,227 unrelated Chinese participants screened for PFO via contrast transthoracic echocardiography (cTTE).

GhRac9 improves cotton resistance to Verticillium dahliae via regulating ROS production and lignin content.

Rac/Rop proteins, a kind of unique small GTPases in plants, play crucial roles in plant growth and development and in response to abiotic and biotic stresses. However, it is poorly understood whether cotton Rac/Rop protein genes are involved in mediating cotton resistance to Verticillium dahliae. Here, we focused on the function and mechanism of cotton Rac/Rop gene GhRac9 in the defense response to Verticillium dahliae infection.

CDCA4 promotes bladder cancer progression by JAK/STAT signaling pathway.

Background: The cell division cycle associated 4 (CDCA4) plays a crucial role in various biological processes and is implicated in the progression of several tumors, however, the mechanisms by which it operates in bladder cancer remain unclear.

Methods: Utilizing data from the TCGA and GEO datasets of bladder cancer patients, we analyzed the expression of CDCA4 and its prognostic significance. We then constructed stable overexpression and knockdown bladder cancer cell lines to investigate the effects of CDCA4 on cell proliferation, migration, and invasion in vitro, employing CCK-8, colony formation, transwell, and wound healing assays.

Oviposition-deterrent activity of p-methyl benzaldehyde and 2-hydroxy-5-methoxybenzaldehyde from the extract of Periplocae cortex for the control of Spodoptera frugiperda.

Background: The invasion of Spodoptera frugiperda into China has caused serious losses to the food industry and has developed varying degrees of resistance to various chemical pesticides. Developing new plant-based pesticides is of great significance for the sustainable management of S. frugiperda.

A Novel Self-Opening Transfer Shuttle for the Transfer of Air-Sensitive Sample to Scanning Electron Microscopy.

A self-opening transfer shuttle has been designed and fabricated for the transfer of air-sensitive samples to scanning electron microscopy (SEM). Delayed push out of an airtight sample cabin sealed inside the shuttle allows the protection of the sample from air exposure during the pumping of SEM chamber. A compressed spring is employed to automatically drive the push out of the cabin.

Cross-subject mental workload recognition using bi-classifier domain adversarial learning.

To deploy Electroencephalogram (EEG) based Mental Workload Recognition (MWR) systems in the real world, it is crucial to develop general models that can be applied across subjects. Previous studies have utilized domain adaptation to mitigate inter-subject discrepancies in EEG data distributions. However, they have focused on reducing global domain discrepancy, while neglecting local workload-categorical domain divergence.

Cryo-SEM Investigation of Using Filter Paper as Substrate.

Cryo-electron microscopy (cryo-EM) is a powerful technique capable of investigating samples in a hydrated state, compared to conventional high-vacuum electron microscopy that requires samples to be completely dry. During the drying process, numerous features and details may be lost due to damage caused by dehydration. Cryo-EM circumvents these problems by cryo-fixing the samples, thereby retaining the intact and original features of hydrated samples.

A rare KLHDC4 variant Glu510Lys is associated with genetic susceptibility and promotes tumor metastasis in nasopharyngeal carcinoma.

Various genetic association studies have identified numerous single nucleotide polymorphisms (SNPs) associated with nasopharyngeal carcinoma (NPC) risk. However, these studies have predominantly focused on common variants, leaving the contribution of rare variants to the "missing heritability" largely unexplored. Here, we integrate genotyping data from 3925 NPC cases and 15,048 healthy controls to identify a rare SNP, rs141121474, resulting in a Glu510Lys mutation in KLHDC4 gene linked to increased NPC risk.

Association of resting amygdalar activity with persistent atrial fibrillation mediated by right atrial inflammation activity on F-fluorodeoxyglucose positron emission tomography-computed tomography.

Background: Recent studies have shown that resting amygdalar activity is associated with cardiovascular disease. Nevertheless, the underlying mechanisms that link resting amygdalar activity with persistent atrial fibrillation (PerAF) remain to be comprehensively delineated. We aimed to estimate the association between resting amygdalar activity, right atrium (RA) inflammatory activity, and PerAF.

Identification of novel germline mutations in FUT7 and EXT1 linked with hereditary multiple exostoses.

Hereditary multiple exostoses (HME) is an autosomal dominant skeletal disorder primarily linked with mutations in Exostosin-1 (EXT1) and Exostosin-2 (EXT2) genes. However, not all HME cases can be explained by these mutations, and its pathogenic mechanisms are not fully understood. Herein, utilizing whole-exome sequencing and genetic screening with a family trio design, we identify two novel rare mutations co-segregating with HME in a Chinese family, including a nonsense mutation (c.

Surface engineering activation of mixed valence copper selenide: A high-performance anode for long life zinc-ion rock-chair batteries.

Rechargeable aqueous zinc-ion batteries (AZIBs) are an attractive alternative to lithium-ion batteries (LIBs) for large-scale energy storage, which offer high ionic conductivity and environmental advantages. However, challenges such as dendrite growth and limited coulombic efficiency (CE) limit electrochemical performance of AZIBs thus hindering their practical application. This study designs a polypyrrole (PPy)-coated copper selenide composite (CuSe@PPy) that works via Zn insertion/extraction mechanism.

Identification, In Silico Selection, and Mechanistic Investigation of Anti-Prostatic Hyperplasia Peptides From Syngnathus schlegeli.

Pipefish is traditionally used as a male tonic in China. Recent studies have shown that Syngnathus schlegeli extracts effectively combat benign prostatic hyperplasia (BPH). However, the specific active compounds involved and their mechanisms of action are not fully understood.

Prenatal exposure to elevated ambient temperature may cause bronchopulmonary dysplasia: Evidence from twin pairs across China.

Exposure to high ambient temperature (TM) may affect lung development, but the association of prenatal TM exposure with bronchopulmonary dysplasia (BPD) is unclear. We explored the impact of prenatal TM exposure on BPD, and identify the critical exposure windows. Individual information of participants was collected from 21 hospitals across China.