Hydrophobic PU fabric with synergistic conductive networks for boosted high sensitivity, wide linear-range wearable strain sensor.

Strain sensing fabrics are able to sense the deformation of the outside world, bringing more accurate and real-time monitoring and feedback to users. However, due to the lack of clear sensing mechanism for high sensitivity and high linearity carbon matrix composites, the preparation of high performance strain sensing fabric weaving is still a major challenge. Here, an elastic polyurethane(PU)-based conductive fabric(GCPU) with high sensitivity, high linearity and good hydrophobicity is prepared by a novel synergistic conductive network strategy.

Reliability assessments of using different heavy metals from remote sediment records to reconstruct historical pollution.

Interpreting heavy metal variations in sedimentary records is an important approach to understand historical pollution. However, few studies have investigated the reliability of different heavy metals in sedimentary records for reconstructing historical pollution. This study retrieved two adjacent lakes' sediment cores from a remote area in North China and investigated their temporal changes in excessive metal fluxes.

Effect of Long-Term Taurine Supplementation on the Lipid and Glycaemic Profile in Adults with Overweight or Obesity: A Systematic Review and Meta-Analysis.

Background: Taurine has been demonstrated to regulate and improve metabolic health. However, physiological and pathological differences among individuals with overweight or obesity may result in varied responses to taurine supplementation. This study aims to estimate the effects of long-term taurine supplementation on blood lipids, glycemia, and insulin sensitivity in adults with overweight or obesity through a systematic review and meta-analysis.

Evaluation of the cross-immunity between Mycobacterium tuberculosis and Mycobacterium abscessus in vitro.

Mycobacterium tuberculosis (M. tuberculosis) and Mycobacterium abscessus (M. abscessus) are important pathogens that can cause lung diseases.

The clinical features and outcomes of elderly patients with acute myeloid leukemia: a real word research.

The aim of this study was to investigate the clinical features and outcomes of elderly patients with acute myeloid leukemia (AML) from a real word research. The clinical data of 223 consecutive elderly patients (aged ≥ 60 years) who were newly diagnosed with AML at our medical center between July 2017 and June 2022, including their clinical characteristics, genetic mutations, and survival outcomes, were retrospectively analyzed. Among the 223 patients (median age 67 years), 180 (80.

Mechanisms of gut homeostasis regulating Th17/Treg cell balance in PMOP.

Postmenopausal osteoporosis (PMOP) is a metabolic bone disease driven by estrogen deficiency, primarily manifesting as reduced bone mass and heightened fracture risk. Its development is intricately linked to the balance between Th17 and Treg cells. Recent studies have highlighted the significant role of gut homeostasis in PMOP.

Genetic polymorphism in β-site amyloid precursor protein-cleaving enzyme 1 affects the structure of medial temporal lobe and cognition in Alzheimer's disease: an exploratory study.

The β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) gene polymorphism (rs638405) has been widely reported to be associated with Alzheimer's disease (AD) risk. However, studies on the relationship between BACE1 gene polymorphism (rs638405), brain volume, and cognition in AD patients remain scarce. To investigate the effect of genetic polymorphism in BACE1 on gray matter volume (GMV) and cognition in AD, this study recruited 111 cognitively unimpaired (CU) controls and 144 AD patients.

Improved prediction of swimming talent through random forest analysis of anthropometric and physiological phenotypes.

Unlabelled: The field of competitive swimming lacks broadly applicable predictive models for talent identification across various age groups of adolescent swimmers. This study aimed to construct a predictive model for athletic talent using machine learning methods based on anthropometric and physiological data. Baseline data were collected from 5444 participants aged 10-18 in Shanghai, China, between 2015 and 2018, with 4969 completing a 3-year follow-up.

Identification of Brain Cell Type-Specific Therapeutic Targets for Glioma From Genetics.

Background: Previous research has demonstrated correlations between the complex types and functions of brain cells and the etiology of glioma. However, the causal relationship between gene expression regulation in specific brain cell types and glioma risk, along with its therapeutic implications, remains underexplored.

Methods: Utilizing brain cell type-specific cis-expression quantitative trait loci (cis-eQTLs) and glioma genome-wide association study (GWAS) datasets in conjunction with Mendelian randomization (MR) and colocalization analyses, we conducted a systematic investigation to determine whether an association exists between the gene expression of specific brain cell types and the susceptibility to glioma, including its subtypes.

Older adults' self-perception, technology anxiety, and intention to use digital public services.

To improve the happiness of the older adults enjoying digital public services, this study examines the structural relationship among self-perception of aging, subjective well-being, technology anxiety, self-efficacy, perceived usefulness, and intention to use digital public services for older adults in the context of digital public services. We employ Structural Equation Modeling (SEM) for empirical analysis (N = 345, February to October 2023). The negative self-perception of aging may lead to the negative emotions of older adults on technology, which will reduce subjective well-being and increase technology anxiety.

Increased epicardial adipose tissue is associated with left ventricular reverse remodeling in dilated cardiomyopathy.

Background: Epicardial adipose tissue (EAT) has been suggested to play paradoxical roles in patients with heart failure. The role of EAT in dilated cardiomyopathy (DCM) patients remains unclear. We aimed to assess the associations between the dynamic changes EAT and left ventricular reverse remodeling (LVRR) in DCM patients based on baseline and follow-up CMR.

Differential regulation of pruritic sensation and emotion by cannabinoid type 1 receptors on mPFC glutamatergic and GABAergic neurons.

Itch causes a strong urge to scratch and induces negative emotions, such as aversion and anxiety. Antihistamine medications are key in the clinical management of pruritus, but their therapeutic efficacy in controlling moderate and severe itching remains limited. The neural circuits in the brain that process itching and itch-induced aversion and anxiety remain unclear so far.

Radiographic biomarkers on grayscale gradient transition zone improve differentiation of deep caries/reversible pulpitis and chronic pulpitis through diagnostic model analysis.

Objectives: To explore the effectiveness of radiographic biomarkers on transition area (TA)-the grayscale gradient zone from carious lesion to normal dentine on radiographs-for identifying deep caries/reversible pulpitis and chronic pulpitis via diagnostic model analysis.

Methods: This retrospective study included 392 caries cases. Canny edge detection was used to define the TA region.

A deep learning approach predicting the activity of COVID-19 therapeutics and vaccines against emerging variants.

Understanding which viral variants evade neutralization is crucial for improving antibody-based treatments, especially with rapidly evolving viruses like SARS-CoV-2. Yet, conventional assays are labor intensive and cannot capture the full spectrum of variants. We present a deep learning approach to predict changes in neutralizing antibody activity of COVID-19 therapeutics and vaccine-elicited sera/plasma against emerging viral variants.

Shugan Jianpi Formula attenuate liver fibrosis via regulation of miR-193a-3p/TGF-β2 in hepatic stellate cells: An in vivo and in vitro study.

Ethnopharmacological Relevance: The Chinese herbal medicine Shugan Jianpi Formula (SGJPF) has traditionally been used to treat various chronic liver disorders. Previous studies have indicated that SGJPF inhibits hepatic stellate cells (HSCs) activation in rats with liver fibrosis (LF) and that miR-193a-3p may be a crucial molecule in LF. However, the mechanisms by which SGJPF regulates HSCs activation through miR-193a-3p remain unclear.

Manipulating Aggregate Electrochemistry for High-Performance Organic Redox Flow Batteries.

Organic molecule in solutions is the energy storage unit in the organic redox flow batteries (ORFBs), of which the aggregation is acknowledged pivotal but has been rarely investigated. By establishing a pyridinium library, the manipulation over the aggregation in solutions is investigated at the molecular level. Both theoretical calculations and physiochemical methods are used to characterize the aggregate's structure, and salient findings are as follows.

Synchronized autologous T-cell immunotherapy with hyperthermia to previously heavy treated advanced renal cell carcinoma.

Purpose: Immune checkpoint inhibitors (ICIs) and target therapy have provided the clinical efficacy for improving the clinical progression-free survival (PFS) and overall survival (OS) for patients with renal cell carcinoma (RCC). There has been little report of an surrogate salvage treatment for those failure of both ICIs and target. An innovation therapeutic model named SHAPE-T (synchronized hyperthermia with autologous progenitor expanded T cells) was applied to previously heavily treated metastatic RCC (mRCC).

Survival causal rule ensemble method considering the main effect for estimating heterogeneous treatment effects.

With an increasing focus on precision medicine in medical research, numerous studies have been conducted in recent years to clarify the relationship between treatment effects and patient characteristics. The treatment effects for patients with different characteristics are always heterogeneous, and therefore, various heterogeneous treatment effect machine learning estimation methods have been proposed owing to their flexibility and high estimation accuracy. However, most machine learning methods rely on black-box models, preventing direct interpretation of the relationship between patient characteristics and treatment effects.

Fostering holistic eye care for children with special educational needs: an interprofessional education program bridging optometry and education.

Purpose: This study outlines the initiation of an interprofessional education (IPE) program designed for optometry and education students. The program aimed to foster interdisciplinary collaboration and improve the management of eye health in children with special educational needs (SEN) - a vulnerable and underserved group.

Methods: This program incorporated lectures and workshops to impart essential knowledge about SEN and to develop the necessary attitudes and skills for conducting eye examinations.

Screening for Fabry disease in patients with hypertrophic cardiomyopathy using cardiac magnetic resonance imaging.

Background: Fabry disease (FD) usually mimics hypertrophic cardiomyopathy (HCM). Decreased native T1 mapping and a unique late gadolinium enhancement (LGE) pattern by cardiac magnetic resonance (CMR) imaging are specific imaging markers for FD.

Purpose: Explore the performance of multiparametric CMR imaging in screening for FD in patients with a HCM phenotype.

Subjective Wearing Experience of Lehfilcon A Among Satisfied Comfilcon A Toric Lens Wearers.

Purpose: To evaluate the subjective wearing experience of lehfilcon A toric lenses among subjects who were already satisfied with their comfilcon A toric lenses.

Methods: This was an open-label, single arm study of currently satisfied comfilcon A soft toric contact lens (Biofinity Toric, CooperVision, Pleasanton, CA) wearers that were refit with lehfilcon A soft toric lenses (Total30 for Astigmatism; Alcon Vision LLC, Fort Worth, TX). Subjects were administered a questionnaire about satisfaction with comfort, visual performance, end of day comfort, and ease of handling with lehfilcon A toric lenses.

Experimental Study on the Effect of HO Concentration on the Degradation of Sulfur Hexafluoride by Two-Stage Tandem DBD.

SF is a greenhouse gas widely used in the power industry that cannot be directly emitted. This study employs a self-designed two-stage dielectric barrier discharge (DBD) plasma series method that was used to degrade SF gas and analyzes the effect of HO concentration. The results indicate that the SF degradation rate (DR) initially increased and then decreased with the rise in the water vapor content.

Distinctive Gait Variations and Neuroimaging Correlates in Alzheimer's Disease and Cerebral Small Vessel Disease.

Background: Both Alzheimer's disease (AD) and cerebral small vessel disease (CSVD) manifest in cognitive impairment and gait disorders. The precise similarities and differences in gait characteristics and underlying neuroimaging mechanisms remain unclear.

Methods: A total of 399 participants were enrolled: 132 with probable AD, including 98 with mild cognitive impairment due to AD (AD-MCI) and 34 with AD dementia, and 185 with CSVD and 82 healthy controls.