Publications by authors named "Wan Hui Wong"

Activated partial thromboplastin time (aPTT)-based clot waveform analysis (CWA) is a plasma-based global haemostatic assay. Elevated CWA parameters have been associated with hypercoagulability in venous thromboembolism, but its role in arterial thrombotic disease is uncertain. This study aims to explore the relationship between aPTT-based CWA and acute myocardial infarction (AMI) and its complications.

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(1) Background: The activated partial thromboplastin time (APTT)- based clot waveform analysis (CWA) quantitatively extends information obtained from the APTT waveform through its derivatives. However, pre-analytical variables including reagent effects on the CWA parameters are poorly understood and must be standardized as a potential diagnostic assay. (2) Methods: CWA was first analysed with patient samples to understand reagent lot variation in three common APTT reagents: Pathromtin SL, Actin FS, and Actin FSL.

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Article Synopsis
  • The study aims to evaluate the relationship between activated partial thromboplastin time (aPTT)-based clot waveform analysis (CWA) and thrombin generation assays (CAT) in warfarin-treated patients with varying International Normalized Ratios (INR).
  • Researchers analyzed a total of 54 samples with INR levels ranging from 1.33 to 6.89, assessing parameters like endogenous thrombin potential (ETP) and peak thrombin in relation to CWA's performance metrics.
  • The results showed a significant correlation between peak thrombin and CWA parameters, particularly with adjusted values, highlighting the potential of CWA in understanding global haemostasis in anticoagulated patients.
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Article Synopsis
  • COVID-19 caused by SARS-CoV-2 and other respiratory viruses both have links to thrombotic complications, but the differences in their prothrombotic potential are not fully understood.
  • A study compared thrombotic rates and coagulation profiles between COVID-19 patients and those with non-CoV-2 respiratory viral infections, revealing low event rates of myocardial infarction in severely ill patients but no significant differences in coagulation parameters during mild COVID-19.
  • The findings suggest that hypercoagulability is more pronounced in severe COVID-19 cases, indicating the need for personalized thromboprophylaxis strategies rather than a one-size-fits-all approach for hospitalized patients.
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Infections cause varying degrees of haemostatic dysfunction which can be detected by clot waveform analysis (CWA), a global haemostatic marker. CWA has been shown to predict poor outcomes in severe infections with disseminated intravascular coagulopathy. The effect of less severe bacterial and viral infections on CWA has not been established.

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Introduction: A hypercoagulable state is a predisposition for venous thromboembolism (VTE). The activated partial thromboplastin time (aPTT)-based clot waveform analysis (CWA) is a global haemostatic measure but its role in assessment of hypercoagulability and thrombotic disorders is uncertain. We aimed to study the changes of CWA parameters in acute VTE.

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Background/objectives: We compared the ex vivo haemostatic capacity of RTFP24 with FFP upon thawing and >24 h post-thaw. We included thrombin generation (TG) as few studies had compared global haemostatic function, and most did not directly compare RTFP24 with FFP >24 h post-thaw.

Materials/methods: Twenty units each of RTFP24 and FFP were measured for coagulation factors and thrombin generation upon thawing (D0) and 4 days post-thaw (D4).

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Non-transfusion-dependent thalassaemia (NTDT) is associated with a hypercoagulable state with thrombotic risk highest after splenectomy. Various mechanisms have been proposed. Although an antiplatelet agent is commonly recommended as thromboprophylaxis in NTDT, the role of platelets contributing to this hypercoagulable state is not well-defined.

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Race is touted as an independent risk factor for venous thromboembolism (VTE), although the basis for this is varied and contentious. Comparison of plasma thrombin generation (TG) using calibrated automated thrombogram (CAT) across races offers a modality that objectively measures global hemostatic function to evaluate this influence. Direct comparative data across races are currently not available.

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Purpose: Herbs with "blood-activating" properties by traditional medicine theory often raise concerns for their possible anti-platelet or anticoagulation effects based on reports from in vitro studies. Such herbs have been implicated for bleeding manifestations based on only anecdotal reports. In particular, the combination of such herbs with anti-platelet agents is often empirically advised against despite lack of good clinical evidence.

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Introduction: Direct oral anticoagulants (DOACs) are establishing themselves as principle choices for the treatment of a variety of thrombotic disorders. DOACs are also known to affect common coagulation tests which are routinely performed for patients in clinical practice. An understanding of their varied effects is crucial for the appropriate ordering of coagulation tests and their interpretation.

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