Publications by authors named "Wan Chenyi"
Ischemic strokes pose serious risks to human health. We aimed to elucidate the function of NOD-like receptor X1 (NLRX1) in a rat middle cerebral artery occlusion (MCAO)-induced cerebral ischemia/reperfusion injury (CIRI) model and in an oxygen-glucose deprivation/reperfusion (OGD/R)-treated human microglial cell line (HMC3) model. Following NLRX1 upregulation, infarct volumes were measured with 2,3,5-triphenyltetrazolium chloride staining and pathological examination was conducted with hematoxylin-eosin staining.
View Article and Find Full Text PDFObjective: The objective of this study was to investigate the cytological features and diagnostic significance of cerebrospinal fluid (CSF) in bacterial meningitis (BM).
Material And Methods: Patients diagnosed with BM at the First Affiliated Hospital of Nanchang University Hospital between August 2021 and April 2022 were enrolled. Clinical, cranial imaging, CSF-next-generation sequencing, CSF examination, and CSF cytology data were retrospectively analyzed.
Neurologists have a difficult time identifying sporadic cerebellar ataxia. Multiple system atrophy of the cerebellar type (MSA-C), spontaneous late cortical cerebellar atrophy, and prolonged alcohol use are a few possible causes. In a group of people with sporadic cerebellar ataxia that was not MSA-C, an autosomal-dominant spinocerebellar ataxia (SCA) mutation was recently discovered.
View Article and Find Full Text PDFPrevious studies by us and others have shown that RING finger protein 213 (RNF213) is associated with cerebrovascular disease and systemic vasculopathy. Indeed, Rnf213 mRNA expression is increased in cerebral ischemia reperfusion injury (CIRI). The purpose of the present study was to investigate the role of Rnf213 in CIRI.
View Article and Find Full Text PDFEfficacy of Heshouwu () on gut mircobiota in mice with autoimmune encephalomyelitis.
J Tradit Chin Med
August 2023
Article Synopsis
- - The study aimed to explore the effects of Heshouwu, a Traditional Chinese Medicine (TCM), on neuroprotection and gut microbiota changes in a mouse model of multiple sclerosis (EAE).
- - Mice treated with different doses of Heshouwu showed reduced disease severity, improved neuro-pathology, and changes in gut microbiota diversity, alongside altered levels of specific immune cells and cytokines.
- - The results indicate that Heshouwu may benefit the immune response by modulating T cell dynamics and enhancing gut microbiota balance, suggesting its potential role in treating autoimmunity-related disorders.
Article Synopsis
- - Spinocerebellar ataxias (SCAs) are a group of genetic neurodegenerative diseases, primarily affecting coordination and movement, and are often caused by certain repeat expansions in DNA that lead to polyglutamine (polyQ) proteins.
- - These diseases primarily impact the cerebellum, which is crucial for controlling eye movements, resulting in various oculomotor impairments that are characteristic of different SCA types.
- - The review discusses the eye movement abnormalities and genetic, clinical, and neuropathological aspects of common polyQ-SCAs, highlighting that analyzing these eye movements can aid in accurately diagnosing these disorders.
Urinary Metabolite Signatures for Predicting Elderly Stroke Survivors with Depression.
Neuropsychiatr Dis Treat
March 2021
Article Synopsis
- - The study investigates the lack of objective diagnostic methods for post-stroke depression (PSD) in elderly stroke survivors by identifying potential urinary biomarkers.
- - Researchers analyzed urinary metabolite signatures from elderly stroke survivors, distinguishing 124 with PSD from 122 without, and found 13 significant metabolites linked to PSD, including abnormalities in phenylalanine and other amino acid pathways.
- - The findings suggest candidate biomarkers for diagnosing PSD and propose that phenylalanine supplements might help prevent depression in this population, enhancing understanding of PSD's underlying mechanisms.
Article Synopsis
- Heterozygous variants in the BICD2 gene are linked to a form of spinal muscular atrophy (SMALED2), typically causing muscle weakness and atrophy primarily in the lower body.
- The study details a family case where affected individuals showed late adult-onset symptoms and asymmetrical muscle weakness in the legs, contrasting earlier descriptions of the disease.
- MRI and muscle biopsy findings revealed significant fatty infiltration in the legs and a mix of neurogenic and myopathy features, along with the discovery of a new mutation in the BICD2 gene.