Publications by authors named "Waltraud Seyfert-Brandt"
J Thromb Haemost
October 2024
Article Synopsis
- Hemophilia B is an X-linked bleeding disorder caused by mutations in the FIX gene, necessitating continuous FIX replacement therapy, often through complex intravenous methods.
- This study focused on improving new rIX-FP variants, specifically R338L and R338L/E410K, to enhance their effectiveness and explore their potential for subcutaneous administration.
- Results showed that the R338L variant had 4-5 times greater specific activity and was effective in reducing bleeding, requiring significantly lower protein amounts compared to standard treatments.
