Tritiated thymidine and bromodeoxyuridine double-labelling studies on growth factors and oral epithelial proliferation in the mouse.

Mouse tongue epithelium is characterized by a circadian variation in the number of cells undergoing DNA synthesis. Groups of male BDF1 mice were followed over 48 h and a double-labelling method with tritiated thymidine and bromodeoxyuridine used to determine S-phase labelling indices, together with cell influx to and cell efflux from S, at 4-hourly time points. Control animals exhibited diurnal peaks in labelling index at 03:00 with trough activity 12 h later at 15:00.

Ofloxacin-induced seizure.

Objective: To describe a possible case of ofloxacin-induced generalized tonic-clonic seizure. Although the etiology is unknown, ofloxacin most likely precipitated this patient's seizure threshold because of sepsis or secondary to drug accumulation due to the patient's compromised renal function.

Case Summary: A 69-year-old white woman with non-small-cell lung cancer and a history of central nervous system metastatic disease treated with radiation therapy presented to the emergency department with symptoms of urosepsis.

Library and information services to support the education and development of nurses: the management of co-operation and change--a clash of two cultures?

This paper reports on the findings of research conducted by the Department of Information and Library Management and the Information Services Department at the University of Northumbria at Newcastle on behalf of the LINC Health Panel. It aims to investigate the organization and funding of library and information services to the nursing profession since the move of nurse education into higher education. The paper focuses on the lack of co-operation and communication between the National Health Service and higher education cultures in the provision of services to nurses.

Villous tumors of the ampulla Vater.

Patients with villous tumors of the ampulla Vater usually present with jaundice, intermittent or constant, but may seek care for abdominal pain, intestinal hemorrhage, or pancreatitis. Because villous tumors may harbor carcinoma in 30 to 50 per cent of cases, appropriate management may require radical resection. We have managed four patients with villous lesions of the ampulla Vater occurring in 1981, 1992, 1993, and 1995.

Carcinoid tumors of the ampulla of Vater.

Periampullary carcinoid tumors are rare; only 73 have previously been reported in the international literature. We reviewed the records of four patients with carcinoid tumor at Vater's ampulla. The findings were compared to a recent review of the previously reported 73 patients.

OneView strategy aligns physicians with Carilion.

Carilion's OneView strategy will ultimately integrate and link our ambulatory activities to our members, patients and community. It is our technology level to lift Carilion, our physician partners and patients to a new level of communication, cooperation, service and quality health care. It will take several years to complete the project, but by the turn of the century we will have OneView of our ambulatory world.

Implications of the UNNDERPIN study at St George's Hospital, Morpeth, Northumberland.

UNNDERPIN (University of Northumbria at Newcastle DEvelopment of and Research into the Provision of Information to Nurses and nurse educators) was an 8-month research project at St George's Hospital, Morpeth, Northumberland. The general aim of the project has been to undertake an examination of library and information services in a climate of change where user information needs are changing and demanding changed services to be provided to meet those needs in order to support patient care and clinical developments. The paper gives an overview of the project describing its background and presenting a summary of the research findings, conclusions and wider implications of the work.

Library audit: report of the process of undertaking the audit of library services of selected educational providers within the former Northern Region: July 1994.

With the current purchaser/provider split in the NHS the purchaser has a responsibility to evaluate the quality of services provided by the provider. In the past year the Northern and Yorkshire Regional Health Authority expressed an interest in auditing library services supplied from selected education providers. This article attempts to given an account of the experience and focuses on the background, the rationale, the process and the outcomes.

Urinary dysfunction in tropical spastic paraparesis: preliminary urodynamic survey.

Tropical spastic paraparesis is an infection caused by human T lymphotropic virus type 1 (HTLV-1). We present the urodynamic findings in 4 female and 1 male patient with tropical spastic paraparesis. All patients underwent synchronous video-pressure-flow urodynamics, while 3 also underwent electromyographic examination.

Ketorolac and diclofenac for postoperative pain relief following oral surgery.

A double-blind clinical study was designed to compare the efficacy and safety of intramuscular and oral ketorolac, a new non-steroidal anti-inflammatory analgesic with that of diclofenac and placebo for patients undergoing removal of impacted mandibular third molar teeth. Results showed that both analgesic preparations were more effective than placebo (p = 0.0029) and that ketorolac provided a similar degree of pain relief to that of diclofenac.

Survey of library and information use by health-care students.

The study compares and contrasts the usage and views of three groups of health-care students (Pre-Project 2000, Project 2000 and BSc Occupational Therapy) on their library facilities. A literature review is included which underpins the importance of libraries for health-care students. Data was compiled from survey responses.

CD-ROM: towards a strategy for teaching and learning.

Compact Disc Read Only Memory (CD-ROM) represents an exciting innovation in nurse education yet paradoxically has a potential to induce disillusionment and frustration. Purchasers of systems may well find that their investment does not bring the benefits they had been lead to expect. CD-ROM systems have the capacity to generate huge quantities of data on an equally large number of nursing topics.

Renal growth factor expression during the early phase of experimental hydronephrosis.

Unilateral ureteral obstruction in the rat leads to hydronephrosis of the affected kidney and renal cell deletion through the process of apoptosis. We studied this experimental model to determine whether acute alterations in renal growth factor expression might be involved in the initiation of the apoptotic response. Northern blot analysis of hydronephrotic, contralateral and sham operated kidney polyadenylated messenger ribonucleic acid (mRNA) was performed to quantitate the expression of mRNA encoding the growth factors epidermal growth factor, transforming growth factor-beta and insulin-like growth factor II during the first 48 hours following ureteral obstruction.

Cardiopulmonary performance following changes in position and the administration of intravenous Diazemuls.

Twenty healthy volunteers entered a study to assess cardiopulmonary responses, as measured by pulse oximetry, following changes in posture in the dental chair and the administration of Diazemuls (diazepam) in doses sufficient to instill sedation (up to a maximum dose of 20 mg) in the volunteers to a degree such that ptosis was seen. The results indicate that SaO2 values remained above 95 per cent throughout the study. It is concluded that although changes in SaO2 and pulse rate do occur, these differences are not important in healthy individuals, although they may be more serious in patients with pre-existing cardiopulmonary disease.

A nuclear protein is required for thyroid hormone receptor binding to an inhibitory half-site in the epidermal growth factor receptor promoter.

The epidermal growth factor (EGF) receptor (EGFR) promoter is negatively regulated by thyroid hormone and retinoic acid. This regulation can be mapped to a 36-basepair GC-rich region of the promoter (EGFR P/E) that functions autonomously as a promoter and an enhancer when placed in front of the thymidine kinase gene TATA element. Direct high affinity binding of the thyroid hormone receptor (T3R) to this element requires a nuclear protein.

The vasculature of the rat penis: a scanning electron microscopic and histologic study.

As a basis for understanding the mechanism of erection in an animal model frequently used in research in reproductive biology, the angioarchitecture of the penis of the rat has been described using scanning electron microscopy. Study of the penile vasculature of the rat indicates that the corpora cavernosa penis and the corpus spongiosum are independent erectile tissues, each with its own arterial and venous vessels. The large vascular spaces and abundant smooth muscle of the penile crura are compatible with its role in regulating blood flow to more distal penile tissues.

Cystic adrenal masses in the neonate associated with hemihypertrophy and the relation to the Beckwith-Wiedemann syndrome.

We report 2 cases of unilateral, multilocular, cystic adrenal masses in neonates. Both patients demonstrated somatic hemihypertrophy, which is considered to have the same implications as the Beckwith-Wiedemann syndrome in terms of tumor risk. Pathological examination showed multiple, adrenal cysts without evidence of tumor or routine adrenal hemorrhage.

Fracture of the mandible in a child.

If unusual injuries to the teeth are present, these should serve as a warning to practitioners that further investigations may be necessary. In the case reported here an undisplaced fracture of the jaw in a young child was only revealed by radiographic investigation.

Distribution and origin of neuropeptide Y-immunoreactive fibers in the penis of the rat.

The present study investigated the distribution of neuropeptide Y-immunoreactive fibers to the penis of the rat. In the corpora cavernosa penis, a dense plexus of fibers was associated with arteries, intrinsic cavernosal muscle, and veins, including the deep dorsal vein. In the corpus spongiosum, immunoreactive fibers were present around vascular smooth muscle and at the periphery of the acini of the paraurethral glands.

Changes in oxygen saturation using two different sedation techniques.

Pulse oximetry was used to assess the degree of hypoxia observed in patients receiving simple midazolam sedation for removal of lower third molars and compared to that seen in patients receiving a combination sedation technique using nalbuphine and midazolam. Results showed that the degree of hypoxia experienced by patients receiving the combination technique was significantly more profound in both incidence and depth than that seen in the group receiving midazolam alone (p less than 0.05).

Structural analysis of the transmembrane domain of the epidermal growth factor receptor.

The ligand-binding domain of the epidermal growth factor (EGF) receptor is separated from the cytoplasmic protein tyrosine kinase domain by a predicted single transmembrane segment. Antipeptide antibodies prepared against the outer portion of the predicted transmembrane segment confirmed this area was exposed only when cells were treated with permeabilizing agents. To investigate structural requirements for signal transduction by the transmembrane domain, three types of mutant EGF receptor were prepared.