Configural display design techniques considered at multiple levels of evaluation.

Two studies were conducted to examine issues in the design and evaluation of configural displays. Four design techniques (bar graphs/extenders, scale markers/ scale grids, color coding/color layering/color separation, and annotation with digital values) were applied, alone and in combination, to a baseline configural display, forming 10 displays. Two qualitatively different evaluations assessed performance for (A) low-level data probes (quantitative estimates of individual variables) and (B) system control and fault detection tasks.

Strategic decision-making among top executives in acute-care hospitals.

Recent changes within the dynamic healthcare industry have necessitated further assessment of the strategic thought processes associated with financial success. Therefore, this study explored hospital executive's use of a comprehensive strategy-making process and its impact on performance in acute care hospitals. Taken as a whole, the strategy-making process is found to be positively associated with financial performance.

Study of plasma factors associated with neutrophil activation and lipid peroxidation in preeclampsia.

Neutrophil activation occurs in women with preeclampsia and is resolved after delivery. The present study examined whether circulating factors in plasma of women with preeclampsia caused neutrophil activation and lipid peroxidation. Twenty-one women with proteinuric preeclampsia were matched for age and gestational age with 19 normal pregnant women.

Association between the endothelin-1 gene Lys198Asn polymorphism blood pressure and plasma endothelin-1 levels in normal and pre-eclamptic pregnancy.

Objective: This study examined the frequency of the Lys198Asn polymorphism in the endothelin-1 (ET-1) gene in women with pre-eclampsia and normal pregnancy; and its contribution to levels of plasma ET-1 and blood pressure.

Design And Methods: This was a retrospective study examining the frequency of the ET-1 Lys198Asn polymorphism in 72 proteinuric pre-eclamptics and 81 normal pregnant women. Height, weight, blood pressure and plasma ET-1 were measured antenatally and at 6 weeks post-partum.

Anticoagulation in pregnancy and the puerperium.

For the management of acute thrombotic events in pregnancy therapeutic doses of low molecular weight heparins (LMWH) may be used, unless the shorter half-life of intravenous unfractionated heparin (UH) and predictable reversibility by protamine are important. Treatment should be continued up until delivery and into the puerperium. Pregnant women who have had an acute thrombotic event should be delivered by a specialist team.

Calibration of a 7.6 cm x 7.6 cm (3 inch x 3 inch) sodium iodide gamma ray spectrometer for air kerma rate.

An experimental procedure is described for converting a gamma ray spectral measurement from a 7.6 cm x 7.6 cm (3 inch x 3 inch) sodium iodide (NaI) detector to air kerma rate.

Conference on cancer brought nurses together.

I have just returned from York where I attended the three-day conference 'A journey through cancer: Nurses collaborate', which brought together 13 forums, societies and special interest groups of the RCN.

Validation of a new live cell strain system: characterization of plasma membrane stress failure.

Motivated by our interest in lung deformation injury, we report on the validation of a new live cell strain system. We showed that the system maintains a cell culture environment equivalent to that provided by conventional incubators and that its strain ouput was uniform and reproducible. With this system, we defined cell deformation dose (i.

Mechanisms of recruitment in oleic acid-injured lungs.

Lung recruitment strategies, such as the application of positive end-expiratory pressure (PEEP), are thought to protect the lungs from ventilator-associated injury by reducing the shear stress associated with the repeated opening of collapsed peripheral units. Using the parenchymal marker technique, we measured regional lung deformations in 13 oleic acid (OA)-injured dogs during mechanical ventilation in different postures. Whereas OA injury caused a marked decrease in the oscillation amplitude of dependent lung regions, even the most dependent regions maintained normal end-expiratory dimensions.

A randomised controlled trial of dietary energy restriction in the management of obese women with gestational diabetes.

A randomised controlled trial was designed to determine the effect of moderate 30% maternal dietary energy restriction on the requirement for maternal insulin therapy and the incidence of macrosomia in gestational diabetes. Although the control group restricted their intake to a level similar to that of the intervention group (6,845 kiloJoules (kJ) versus 6,579 kJ), the resulting cohort could not identify any adverse effect of energy restriction in pregnancy. Energy restriction did not alter the frequency of insulin therapy (17.

Management of type II dens fractures: a case-control study.

Study Design: A case-control study of patients with isolated type II dens fractures treated with halo vest immobilization.

Objectives: To evaluate age as a risk factor for failure of halo immobilization in patients with type II dens fractures.

Summary Of Background Data: The literature reports an average fusion rate of approximately 70% in patients with type II dens fractures treated by halo vest immobilization.

Impact of lay responder actions on out-of-hospital cardiac arrest outcome.

Introduction: Little peer-reviewed literature exists regarding the actions of the person who recognized and called 911 at the time of an out-of-hospital cardiac arrest (OHCA).

Objectives: To describe the characteristics of persons who recognized OHCAs and to assess the impact of their actions on survival.

Methods: Subjects were a convenience sample of individuals who called 911 after a case of home OHCA in which the victim was transported to one of two suburban community teaching hospitals.

Effects of lipoproteins from pre-eclamptic women on umbilical endothelial cell 6-oxo-prostaglandin f1alpha and endothelin 1 synthesis, and nitric oxide synthase 3 mRNA expression.

In order to evaluate whether lipid abnormalities may contribute to endothelial dysfunction in pre-eclampsia, the present study examined the in vitro effects of very-low-density lipoprotein (VLDL), low-density lipoprotein (LDL) and high-density lipoprotein (HDL), isolated from women with pre-eclampsia and matched controls, on the endothelial synthesis of 6-oxo-prostaglandin F(1alpha) (6-oxo-PGF(1alpha); a metabolite of prostacyclin) and endothelin 1, and on the expression of nitric oxide synthase 3 (NOS3) mRNA. VLDL, LDL and HDL cholesterol were isolated from 20 pre-eclamptic and 20 age- and gestation-matched normal pregnant women. The lipoproteins (50 microgram/ml) and lipoprotein-free control plasma were incubated for 1, 3 and 6 h at 37 degrees C with a human umbilical endothelial cell line.

Is proteinuric pre-eclampsia a different disease in primigravida and multigravida?

This study aimed to identify if the clinical features of proteinuric pre-eclampsia or the biochemical markers of endothelial dysfunction associated with this syndrome are altered according to parity in a direction that would suggest a different pathophysiology. Groups of 27 primigravid and 35 multigravid women with pre-eclampsia (defined as blood pressure >140/90 mmHg and 2+ proteinuria) were studied ante-partum, and at 6 weeks and 6 months post-partum. Clinical markers of severity of pre-eclampsia, including blood pressure, markers of renal, hepatic and coagulatory function, and biochemical markers of endothelial dysfunction were measured.

Does a predisposition to the metabolic syndrome sensitize women to develop pre-eclampsia?

Objective: This study aimed to identify those factors in the non-pregnant state that distinguished women who developed pre-eclampsia from those who had normotensive pregnancies.

Design And Setting: This was a retrospective analysis of anthropometry, blood pressure, biochemical and haematological variables in 62 women with pre-eclampsia and 84 normotensive pregnant women who took part in studies of the pathophysiology of pre-eclampsia. Pregnant volunteers were seen, after admission to hospital or in the outpatient clinic, and followed-up at 6 weeks and 6 months post-partum in the outpatient clinic or their home.