Involvement of functional senescence in efavirenz-induced toxicity in fruit fly.

Background: We aimed in this article to assess the likeliness of efavirenz to induce functional senescence in (fruit fly).

Methods: Ten different concentrations of EFV were mixed with fly food and fed to 3-day-old flies orally for a 7 day LC calculation. Drug concentrations from LC were selected for a 28 day survival to determine the duration of treatment for behavioral and biochemical assays.