Publications by Walter Koelch

Publications by authors named "Walter Koelch"

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Cell surface-bound heat shock protein 70 (Hsp70) mediates perforin-independent apoptosis by specific binding and uptake of granzyme B.

Catharina Gross Walter Koelch Antonio DeMaio Nelson Arispe Gabriele Multhoff

J Biol Chem

October 2003

Cell surface-bound heat shock protein 70 (Hsp70) renders tumor cells more sensitive to the cytolytic attack mediated by natural killer (NK) cells. A 14-amino acid Hsp70 sequence, termed TKD (TKDNNLLGRFELSG, aa450-463) could be identified as the extracellular localized recognition site for NK cells. Here, we show by affinity chromatography that both, full-length Hsp70-protein and Hsp70-peptide TKD, specifically bind a 32-kDa protein derived from NK cell lysates.

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- Walter Koelch's research focuses on the interactions between heat shock proteins and immune cell mechanisms, particularly the role of cell surface-bound heat shock protein 70 (Hsp70) in enhancing the sensitivity of tumor cells to natural killer (NK) cell attacks.
- His seminal 2003 article identifies a specific 14-amino acid Hsp70 sequence, TKD, which serves as a recognition site for NK cell-mediated apoptosis, indicating a potential target for cancer immunotherapy.
- The study employs techniques such as affinity chromatography to demonstrate the specific binding of Hsp70 to a 32-kDa protein in NK cell lysates, further elucidating the complex molecular interactions at play in immune responses against tumors.

Publications by authors named "Walter Koelch"

Cell surface-bound heat shock protein 70 (Hsp70) mediates perforin-independent apoptosis by specific binding and uptake of granzyme B.

Synopsis of recent research by authors named "Walter Koelch"