Publications by authors named "Walter Junior"

Lymphatic filariasis (LF) is a neglected tropical disease associated with poverty and poor environmental conditions. With the inclusion of vector control activities in LF surveillance actions, there is a need to develop simple methods to identify areas with higher mosquito density and thus a higher consequent risk of transmission. An ecological study was conducted in Igarassu, which is in the metropolitan region of Recife, Pernambuco, Brazil.

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  • The study investigates the anti-ulcer effects of hydroalcoholic extract (HETp) and its active component parthenolide (PTL) against gastric ulcers induced by ethanol and piroxicam.
  • Results showed that both HETp and PTL significantly reduced ulcer formation, with additional histological support confirming their effectiveness.
  • The protective effects involve various mechanisms, including the influence of nitric oxide, adrenergic receptors, and prostaglandins, while also enhancing antioxidant levels and reducing harmful enzyme activity.
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  • The COVID-19 pandemic was caused by the SARS-CoV-2 virus, leading to serious health issues including severe respiratory problems and potential death, especially in regions with high rates of HIV and Leishmania infantum infections.
  • A case study of a 48-year-old woman in Brazil showed she was hospitalized for 36 days with a complicated coinfection of SARS-CoV-2, HIV, and Leishmania infantum, experiencing severe symptoms and concerning lab results, including low oxygen saturation and abnormal blood markers.
  • Despite her critical condition and the complications from the coinfection, she was eventually discharged, highlighting the need for more research on how to effectively diagnose and manage patients with similar coexisting infections amid the COVID-19
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Fridericia chica is an Amazonian plant used to treat stomach disorders. However, the pharmacological activity of flavonoids in the extract has yet to be investigated. Therefore, we considered that a flavonoid-rich F.

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  • Major depressive disorder (MDD) significantly impacts quality of life, particularly linked to stress from maternal deprivation (MD), and traditional treatments often have serious side effects.
  • Centella asiatica (C. asiatica) and its compound madecassic acid show promise for alleviating depressive-like behaviors and reducing inflammation and oxidative stress in young rats subjected to MD.
  • The study demonstrated that treatment with C. asiatica extracts led to improvements in behavior, decreased inflammatory markers, and reduced oxidative stress in the brain and serum, suggesting their potential as antidepressant agents.
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 To describe and evaluate the accuracy of the pericapsular nerve group (PENG) block technique with no ultrasound guidance.  Series of 40 infiltrations in patients with hip pain undergoing outpatient follow-up in the hip surgery group or admitted to the emergency room from a hospital in São Paulo, SP, Brazil. The hip PENG technique was guided by palpable anatomical pelvic structures, with no ultrasound orientation for needle positioning, using the equipment only to check the correct location after an unguided puncture.

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 To evaluate the technical reproducibility of a block of the pericapsular nerve group (PENG) of the hip aided or not by ultrasound in cadavers.  The present is a randomized, descriptive, and comparative anatomical study on 40 hips from 2 cadaver groups. We compared the PENG block technique with the method with no ultrasound guidance.

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  • MINS (Myocardial Injury after Noncardiac Surgery) significantly increases the risk of mortality in patients, with a prevalence of 9.4% in a study involving 2,230 patients over a median follow-up of 6.7 years.
  • Variables associated with both early and late mortality include factors like MINS, previous heart issues, urgent surgeries, dementia, peripheral artery disease, and age.
  • Machine learning models were used to identify these predictors, confirming that higher levels of cardiac troponin post-surgery significantly correlate with increased mortality risk.
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Coffee farmers have faced problems due to drought periods, with irrigation being necessary. In this sense, this study aimed to evaluate the responses to different levels and durations of water deficit in arabica coffee genotypes in the Cerrado region. The experiment consisted of three genotypes and five water regimes: full irrigation (FI 100 and FI 50-full irrigation with 100% and 50% replacement of evapotranspiration, respectively), water deficit (WD 100 and WD 50-water deficit from June to September, with 100% and 50% replacement of evapotranspiration, respectively) and rainfed (without irrigation).

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  • Visceral leishmaniasis (VL) is a significant global health issue, particularly among individuals coinfected with HIV, who may experience atypical VL symptoms and a higher risk of disease relapse.
  • This study analyzed cytokine levels in 134 participants (35 symptomatic VL-HIV coinfected, 75 asymptomatic VL-HIV coinfected, and 24 healthy controls) using a specialized testing method to understand differences in immune response.
  • Results showed that symptomatic VL-HIV individuals had elevated levels of specific cytokines (IL-17A, IL-6, and IL-10) compared to both healthy controls and asymptomatic patients, highlighting the potential for these markers in assessing the severity of VL in HIV-coinfected cases
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  • Several studies link deforestation to a rise in infectious diseases, prompting this study to explore how vegetation loss in the Brazilian Cerrado correlates with dengue cases.
  • The research involved quantifying deforestation and dengue cases from 2001 to 2019 and utilized various statistical models to project future trends.
  • Findings show significant vegetation loss in most states, with projected increases in dengue cases by 2030, prompting recommendations for Brazil to control deforestation and enhance public health policies.
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The aim of this study is to evaluate the elemental composition of fifteen algae-based supplements commonly sold in the Portuguese market, by energy dispersive X-ray fluorescence. Despite the fact that the majority of Kelp samples were a good source of iodine, the levels observed might well contribute to an excess in the human body, which can cause dysfunction of the thyroid gland. Furthermore, the presence of lead in Sea spaghetti, Arame, Hijiki and Wakame caused a considerable risk to public health vis a vis possible ingestion of a high daily dose.

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Purpose Of Review: This narrative review will focus on concepts and methods of Information Design and User Experience for patient education in orthopedics, with osteoarthritis as an application example.

Recent Findings: Information design can make complex health information clear according to the needs of the patients. Digital health presents new opportunities to design scalable educational interventions and may be improved with User Experience Design.

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  • Nitazoxanide was tested in a study to see its effects on COVID-19 patients, but it didn’t improve symptom resolution compared to a placebo.
  • The trial involved 392 patients who received either nitazoxanide or a placebo, with findings showing a significant reduction in viral load for those on nitazoxanide.
  • Overall, while nitazoxanide didn’t alleviate symptoms within 5 days, it was found to be safe and effective in lowering the amount of virus present in the body.
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Objective: To map the implementation characteristics of Medicine programs established in Brazilian federal universities from 2013 onwards.

Methods: A qualitative and quantitative exploratory study was performed. Newly created Medicine programs were identified in federal universities, with analysis of pedagogical frameworks and interviews with students, faculty, and health care professionals from associated health care services.

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  • - Multinucleate cell angiohistiocytoma is a rare, non-cancerous skin growth primarily seen in middle-aged women, typically presenting as painless, purple bumps on the hands and feet.
  • - The condition features specific microscopic traits, such as enlarged small blood vessels, thickened collagen in supportive tissue, and the presence of giant cells with multiple nuclei.
  • - A case study highlights a 62-year-old woman diagnosed with this condition who opted out of treatment due to its benign nature, emphasizing key clinical and immunohistological characteristics of the disorder.
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Methamidophos (MET) is a pesticide that has toxic properties, including effects on fertility. This study aimed to assess the joint action of treatment time and exposure to methamidophos on the male reproductive system. MET was orally administered to adult male Swiss mice at a dose of 0.

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Silymarin is a phytotherapeutic agent derived from the species Silybum marianum (Asteraceae), commonly is known as milk thistle, and traditionally used as a hepatoprotective; however, recent studies have proposed its use in order to promote lactogenesis, but there are few reports of its effects on the development of offspring. Thus, the objective of this study was to evaluate the effect of silymarin treatment during pregnancy and breastfeeding on the sensory-somatic-motor development and adult behavior of F1-generation Swiss mice. The pregnant females of the parental generation were distributed in four experimental groups and treated orally with doses of 100, 200 or 300 mg/kg of silymarin, with a control group receiving vehicle - vegetable oil (VEH), to obtain the F1-generation.

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We compare the expression levels of the lactate transporter complex consisting of the lactate transporter, monocarboxylate transporter 1 (MCT1), and its ancillary protein, cluster of differentiation 147 (CD147), in the membranes of red blood cells (RBCs) from two breeds of jumping horses and associate the expression levels of these proteins with their jumping ability. The expression levels of MCT1 and CD147 proteins on the membranes of RBCs collected from 30 show jumping horses of two different breeds were quantified: the Brazilian Sport Horses (n = 17) and the European Warmbloods (n = 13). The levels of MCT1 and CD147 in the RBC membranes were measured by Western blot using horse-specific antibodies.

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 The purpose of the present paper is to compare the equivalence of the measurement of the alpha angle using the Ducroquet and cross-table lateral views.  We have recruited 90 patients, resulting in 95 hips. We have standardized the realization of the radiographic views.

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Few data exist on the physiological consequences of an incremental exercise test (IET) and training in dogs. Here we evaluated the effect of an endurance-training program (ETP) on the kinetics of the serum biomarkers: creatine kinase (CK), aspartate aminotransferase (AST), myoglobin, cardiac troponin I (cTnI), and creatine kinase isoenzyme MB (CK-MB). Eighteen Beagle dogs were assigned to three groups: sedentary (S), untrained (U), and trained (T).

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Objective: Describe the results from arthroscopic surgical treatment on a group of patients who developed symptoms after repetitive physical activity of moving their hips in a position of hyperflexion, as in leg presses and squats.

Methods: The study group comprised 47 individuals (48 hips) who developed the onset of painful symptoms associated with hip hyperflexion exercises (leg presses or squats) and underwent arthroscopic treatment. The patients were evaluated radiographically and clinically according to the "Harris Hip Score", as modified by Byrd (MHHS), pre and postoperatively, and were asked about their return to sports activities and the surgical findings.

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