Publications by authors named "Walter GrossoMarra"
Efficacy and Safety of Clopidogrel, Prasugrel and Ticagrelor in ACS Patients Treated with PCI: A Propensity Score Analysis of the RENAMI and BleeMACS Registries.
Am J Cardiovasc Drugs
June 2020
Article Synopsis
- This study compares the effectiveness and safety of clopidogrel, prasugrel, and ticagrelor in over 19,000 patients with acute coronary syndrome undergoing PCI and looks at the risks of ischemic events and bleeding over time.
- Results show prasugrel leads to significantly lower rates of net adverse clinical events and major adverse cardiovascular events compared to clopidogrel, while ticagrelor also reduces major adverse cardiovascular events but has a higher bleeding risk.
- The analysis indicates that clopidogrel’s risk profile peaks at 3 months for ischemic events while prasugrel maintains a balance between ischemia and bleeding, and ticagrelor consistently reduces heart attacks over
Background: Pathogenesis of cardiovascular disease in HIV-positive patients is related to the interaction between traditional and HIV-specific factors. Limited data are available regarding the prognosis of HIV-positive patients undergoing percutaneous coronary intervention (PCI).
Methods: All observational studies evaluating the prognosis of HIV-positive patients treated with PCI were included.
Background And Aims: The risk of recurrence of myocardial infarction (MI) in HIV patients presenting with acute coronary syndrome (ACS) is well known, but there is limited evidence about potential differences in coronary plaques compared to non-HIV patients.
Methods: In this multicenter case-control study, HIV patients presenting with ACS, with intravascular-ultrasound (IVUS) data, enrolled between February 2015 and June 2017, and undergoing highly active antiretroviral therapy (HAART), were retrospectively compared to non-HIV patients presenting with ACS, before and after propensity score with matching, randomly selected from included centers. Primary end-point was the prevalence of multivessel disease.
The optimal antiaggregant therapy after coronary stenting in patients receiving oral anticoagulants (OACs) is currently debated. MEDLINE and Cochrane Library were searched for studies reporting outcomes of patients who underwent PCI and who were on triple therapy (TT) or dual-antiplatelet therapy (DAPT) with aspirin and clopidogrel or dual therapy (DT) with OAC and clopidogrel. Major bleeding was the primary end point, whereas all-cause death, myocardial infarction (MI), stent thrombosis, and stroke were secondary ones.
View Article and Find Full Text PDFIntroduction: Asymptomatic patients with human immunodeficiency virus (HIV) infection are at increased risk of vascular disease. Whether asymptomatic HIV patients have increased prevalence or structural differences in coronary artery plaques is not clear.
Methods: Pubmed, Cochrane and Google Scholar were searched for articles evaluating asymptomatic HIV patients evaluated with coronary computed tomography.
Aim: This study compares the clinical and angiographic outcomes of sirolimus eluting stent (SES) and bare metal stent (BMS) implantation for unprotected left main coronary artery (ULMCA) stenosis.
Methods And Results: We analysed 141 unselected patients with unprotected LMCA stenosis: 72 were treated with SES and 69 with BMS. SES patients were younger, with a higher ejection fraction, had more often hypertension, family history and were more often smokers.