Publications by authors named "Walter David Cruz-Pineda"
Changes in the Expression of Insulin Pathway, Neutrophil Elastase and Alpha 1 Antitrypsin Genes from Leukocytes of Young Individuals with Insulin Resistance.
Walter David Cruz-Pineda Olga Lilia Garibay-Cerdenares Hugo Alberto Rodríguez-Ruíz Inés Matia-García Linda Anahí Marino-Ortega
Diabetes Metab Syndr Obes
June 2022
Article Synopsis
- Chronic hyperinsulinemia affects insulin signaling gene expression in leukocytes among young individuals with varying weight and insulin resistance profiles.
- A study comparing normal weight individuals without insulin resistance (NIR), those with insulin resistance (IR), and obese individuals with insulin resistance (OB-IR) found significant differences in gene expression primarily in the OB-IR group.
- Results indicated that hyperinsulinemia and obesity correlate with altered expression of genes linked to neutrophil elastase (NE) and alpha 1 antitrypsin (A1AT), suggesting their potential role in insulin signaling pathways.
Insulin is the hormone responsible for maintaining glucose homeostasis in the body, in addition to participating in lipid metabolism, protein synthesis, and the inhibition of gluconeogenesis. These functions are well characterized in the classic organ target cells that are responsible for general energy regulation: the liver, skeletal muscle, and adipose tissue. However, these actions are not restricted to these tissues because insulin has been shown to affect most cells in the body.
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