GAD65 antigen therapy in recently diagnosed type 1 diabetes mellitus.

Background: The 65-kD isoform of glutamic acid decarboxylase (GAD65) is a major autoantigen in type 1 diabetes. We hypothesized that alum-formulated GAD65 (GAD-alum) can preserve beta-cell function in patients with recent-onset type 1 diabetes.

Methods: We studied 334 patients, 10 to 20 years of age, with type 1 diabetes, fasting C-peptide levels of more than 0.

Diabetes and neurodegeneration in Wolfram syndrome: a multicenter study of phenotype and genotype.

Objective: To describe the diabetes phenotype in Wolfram syndrome compared with type 1 diabetes, to investigate the effect of glycemic control on the neurodegenerative process, and to assess the genotype-phenotype correlation.

Research Design And Methods: The clinical data of 50 patients with Wolfram syndrome-related diabetes (WSD) were reviewed and compared with the data of 24,164 patients with type 1 diabetes. Patients with a mean HbA1c during childhood and adolescence of ≤7.

[Application of standardized patients in teaching, learning and assessment].

The new German requirements for Licensure to practice medicine focus on teaching clinical skills. It will become difficult for Medical Schools to fulfil these new requirements in the training of medical students with the increasing cost effectiveness in patient care. Standardized patients can be a very useful tool in teaching clinical skills.

First year medical students' perceptions of stress and support: a comparison between reformed and traditional track curricula.

Background: The authors hypothesised that medical schools need to support their students by identifying the challenges inherent in the demanding study of medicine, especially during the transitional phase at the beginning of study. Therefore, a study was conducted to evaluate Year 1 students' perceptions on how well 2 different programmes--a reformed and a traditional programme--helped students make a good start to their studies.

Design: Cross-sectional survey.