Synopsis of recent research by authors named "Walter A Korfmacher"
- Walter A. Korfmacher's recent research primarily focuses on the development and optimization of histamine H3-receptor antagonists, with significant work on the synthesis of benzimidazolone derivatives and their structure-activity relationships, revealing their potent binding affinities and functional activities.
- His studies also emphasize innovative analytical methodologies, such as Liquid Extraction Surface Analysis Mass Spectrometry (LESA-MS) and Matrix-Assisted Laser Desorption/Ionization (MALDI) imaging, to facilitate drug distribution and metabolism investigations, which improve the profiling of drug candidates in tissues.
- Korfmacher advocates for the integration of early drug metabolism and pharmacokinetic (DMPK) evaluation in the drug discovery paradigm, suggesting that it enhances the efficiency of selecting viable drug candidates and reduces overall attrition rates in drug development.
