Envisioning the Near Future of Community Pharmacy Patient Care Practice: Report of the 2023-2024 AACP Professional Affairs Standing Committee.

The 2023-2024 Professional Affairs Committee was charged to (1) Create an action plan in response to the clear urgent need for transformation of community pharmacy practice; and (2) Develop "readiness for change" instrument that addresses multiple pharmacy stakeholder groups that are based on the ACT "community pharmacy enhanced services" definition. Due to the continuous and rapid-paced changes occurring in community pharmacy practice, the committee developed a document that provides the baseline elements that should be considered for community pharmacy practice currently and into the future. This document, Envisioning the Near Future of Community Pharmacy Patient Care Practice: Key Elements of Practice Redesign in Community Pharmacies, contains 8 sections and is recommended to be socialized within the pharmacy profession to ensure that it resonates with current and future community pharmacy practice.

A Mindfulness-Based Intervention for Acute Care Nursing Staff: A Pilot Study.

The purpose of this study was to determine if a mindfulness-based smartphone application, used for 5 minutes a day for 30 days, could address burnout among acute care nursing staff. A pretest-posttest design with a midpoint evaluation was utilized. The sample included 31 nursing staff from cardiovascular acute care units.

Using the Health Belief Model to Examine Adherence to Preventive Measures Among Nursing Students During COVID-19: A Cross-Sectional Analysis.

Associations between health belief model constructs and engagement in COVID-19 preventive practices were examined in a population of 234 nursing students. Most (93 percent/68 percent, respectively) reported occasionally/frequently performing 6-feet physical distancing and wearing face masks/covering in public. Among health belief model constructs, perceived benefits were significantly associated with practicing physical distancing; perceived barriers were associated with lower likelihood.

Examining the associations between self-care practices and psychological distress among nursing students during the COVID-19 pandemic.

There is limited research regarding the impact of self-care practices on psychological distress, specifically on nursing students during a pandemic, such as COVID-19 (Corona Virus Disease- 2019). A 10-minute electronic survey was sent to nursing students at a large academic-medical center, and data from 285 student respondents were analyzed to assess psychological status, attitudes and behaviors in regards to the COVID-19 pandemic. Significant differences were found when comparing self-care practice scores by school grade for total scores (F = 4.

Acute In Vivo Multielectrode Recordings from the Mouse Suprachiasmatic Nucleus.

The discovery of the suprachiasmatic nucleus (SCN) as the master mammalian pacemaker has since opened up a variety of alternative methods for assessing how external timing cues influence the clock. One powerful approach for understanding how sensory inputs influence the SCN is to monitor acute changes in SCN electrophysiological activity via in vivo extracellular recording. This methodology offers the ability to monitor stimulus-evoked changes in SCN function at very fine timescales and to rapidly test multiple stimuli and/or stimulus repeats within a single animal.

Output from VIP cells of the mammalian central clock regulates daily physiological rhythms.

The suprachiasmatic nucleus (SCN) circadian clock is critical for optimising daily cycles in mammalian physiology and behaviour. The roles of the various SCN cell types in communicating timing information to downstream physiological systems remain incompletely understood, however. In particular, while vasoactive intestinal polypeptide (VIP) signalling is essential for SCN function and whole animal circadian rhythmicity, the specific contributions of VIP cell output to physiological control remains uncertain.

CPR to the Rescue!: An Interprofessional Pilot Program: Cultivating Practices for Resilience (CPR) Camp.

Purpose/objectives: The hCATS (health Colleges Advancing Team Skills) to CPR (Cultivating Practices for Resilience) Camp was an interprofessional pilot program to promote resilience, introduce strategies for coping with stress, cultivate compassion, and promote work-life balance to prevent burnout among health profession students, faculty, and healthcare professionals who team to provide patient care.

Program Description: The University of Kentucky (UK) College of Nursing received funding to partner with the UK Center for Interprofessional Health Education for immersive weekend activities utilizing KORU and Mindfulness Based Stress Reduction models, conducted by certified UK faculty experts in self-stewardship techniques such as mindfulness practices.

Outcomes: Thirty-nine participants from 7 UK colleges and UK HealthCare participated in 4 distinct CPR Camps, completed program assessments, and created team projects.

Commissural communication allows mouse intergeniculate leaflet and ventral lateral geniculate neurons to encode interocular differences in irradiance.

Key Points: Unlike other visual thalamic regions, the intergeniculate leaflet and ventral lateral geniculate nucleus (IGL/vLGN) possess extensive reciprocal commissural connections, the functions of which are unknown. Using electrophysiological approaches, it is shown that commissural projecting IGL/vLGN cells are primarily activated by light increments to the contralateral eye while cells receiving commissural input typically exhibit antagonistic binocular responses. Across antagonistic cells, the nature of the commissural input (excitatory or inhibitory) corresponds to the presence of ipsilateral ON or OFF visual responses and in both cases antagonistic responses disappear following inactivation of the contralateral thalamus.

Experiential interprofessional education for medical students at a regional medical campus.

Background: Regional medical campuses are often challenged with providing effective interprofessional education (IPE) opportunities for medical students that are comparable to those at main campuses. At distributed teaching sites, there is often less IPE infrastructure and fewer learners of other health professions. On the other hand, distributed medical education (DME) settings often have community-based clinical environments and fewer medical students, which can provide unique opportunities for IPE curriculum innovation.

Rods progressively escape saturation to drive visual responses in daylight conditions.

Rod and cone photoreceptors support vision across large light intensity ranges. Rods, active under dim illumination, are thought to saturate at higher (photopic) irradiances. The extent of rod saturation is not well defined; some studies report rod activity well into the photopic range.

Non-linear conduction due to depinning of charge order domains in FeOBO.

The oxyborate FeOBO presents a charge density wave (CDW) transition close to room temperature. As we show here, this is associated with a well defined anomaly in the specific heat. Below this transition, when applying in a single crystal of FeOBO a DC voltage above a temperature dependent threshold, a high current is liberated in this material.

Geniculohypothalamic GABAergic projections gate suprachiasmatic nucleus responses to retinal input.

Key Points: Visual input to the suprachiasmatic nucleus circadian clock is critical for animals to adapt their physiology and behaviour in line with the solar day. In addition to direct retinal projections, the clock receives input from the visual thalamus, although the role of this geniculohypothalamic pathway in circadian photoreception is poorly understood. In the present study, we develop a novel brain slice preparation that preserves the geniculohypothalamic pathway to show that GABAergic thalamic neurons inhibit retinally-driven activity in the central clock in a circadian time-dependent manner.

Visual input to the mouse lateral posterior and posterior thalamic nuclei: photoreceptive origins and retinotopic order.

Key Points: The lateral posterior and posterior thalamic nuclei have been implicated in aspects of visually guided behaviour and reflex responses to light, including those dependent on melanopsin photoreception. Here we investigated the extent and basic properties of visually evoked activity across the mouse lateral posterior and posterior thalamus. We show that a subset of retinal projections to these regions derive from melanopsin-expressing retinal ganglion cells and find many cells that exhibit melanopsin-dependent changes in firing.

A novel horizontal photobioreactor for high-density cultivation of microalgae.

Microalgae are a promising source of biofuels and bioproducts, as they consume CO2 to grow, multiply quickly, and can be cultivated in wastewater and on marginal land. Development of low-cost and high-efficiency microalgal cultivation systems is important to the cost-competitiveness of algae. A floating horizontal photobioreactor (HBR) was developed that is inexpensive and scalable, as it is manufactured from inexpensive plastic film and is modular.

Colour as a signal for entraining the mammalian circadian clock.

Twilight is characterised by changes in both quantity ("irradiance") and quality ("colour") of light. Animals use the variation in irradiance to adjust their internal circadian clocks, aligning their behaviour and physiology with the solar cycle. However, it is currently unknown whether changes in colour also contribute to this entrainment process.

Eye-specific visual processing in the mouse suprachiasmatic nuclei.

Internal circadian clocks are important regulators of mammalian biology, acting to coordinate physiology and behaviour in line with daily changes in the environment. At present, synchronisation of the circadian system to the solar cycle is believed to rely on a quantitative assessment of total ambient illumination, provided by a bilateral projection from the retina to the suprachiasmatic nuclei (SCN). It is currently unclear, however, whether this photic integration occurs at the level of individual cells or within the SCN network.

Binocular integration in the mouse lateral geniculate nuclei.

A key task for the visual system is to combine spatially overlapping representations of the environment, viewed by either eye, into a coherent image. In cats and primates, this is accomplished in the cortex [1], with retinal outputs maintained as separate monocular maps en route through the lateral geniculate nucleus (LGN). While this arrangement is also believed to apply to rodents [2, 3], this has not been functionally confirmed.

Evidence of weak ferromagnetism in doped plasticized polyaniline (PANI-DDoESSA)0.5 from electron spin resonance measurements.

X-band electron spin resonance (ESR) measurements have been performed on a conducting free-standing film of polyaniline plasticized and protonated with di-n-dodecyl ester of sulfosuccinic acid (DDoESSA). The magnetic field was applied parallel and perpendicular to the plane of the film. At around 75 K a transition is observed from Pauli susceptibility to a localized state in which the spin 1/2 polarons behave as spin 1/2 dimers.

Magnetic field dependence of the magnetic susceptibility and the specific heat of the doped plasticized polyaniline (PANI-DB3EPSA)0.5.

Specific heat, magnetization and electron spin resonance (ESR) data obtained from a self-standing film of the doped plasticized polyaniline (PANI-DB3EPSA)(0.5) are shown. No long range magnetic order has been observed at zero magnetic field, above 2 K.

From molecular control to quantum technology with the dynamic Stark effect.

The non-resonant dynamic Stark effect is a powerful and general way of manipulating ultrafast processes in atoms, molecules, and solids with exquisite precision. We discuss the physics behind this effect, and demonstrate its efficacy as a method of control in a variety of systems. These applications range from the control of molecular rotational dynamics to the manipulation of chemical reaction dynamics, and from the suppression of vacuum fluctuation effects in coherent preparation of matter, to the dynamic generation of bandwidth for storage of broadband quantum states of light.

Context-dependent cell cycle checkpoint abrogation by a novel kinase inhibitor.

Background: Checkpoint kinase 1 and 2 (Chk1/Chk2), and the Aurora kinases play a critical role in the activation of the DNA damage response and mitotic spindle checkpoints. We have identified a novel inhibitor of these kinases and utilized this molecule to probe the functional interplay between these two checkpoints.

Principal Findings: Fragment screening, structure guided design, and kinase cross screening resulted in the identification of a novel, potent small molecule kinase inhibitor (VER-150548) of Chk1 and Chk2 kinases with IC(50)s of 35 and 34 nM as well as the Aurora A and Aurora B kinases with IC(50)s of 101 and 38 nM.

A pilot project to evaluate the academic performance, abilities, and satisfaction of second-degree students.

The literature on students matriculated in the growing number of second-degree nursing programs in the United States typically describes them as exceptional on many parameters of interest. The experience at the authors' university in an integrated second-degree baccalaureate nursing program did not support prevailing notions regarding these students. The purpose of this pilot project was to evaluate the performance and satisfaction of second-degree students in comparison to traditional students.

Trophic activity of Rabies G protein-pseudotyped equine infectious anemia viral vector mediated IGF-I motor neuron gene transfer in vitro.

The present study examines gene delivery to cultured motor neurons (MNs) with the Rabies G protein (RabG)-pseudotyped lentiviral equine infectious anemia virus (RabG.EIAV) vector. RabG.