A mixed-methods study to identify the top 10 research priorities for perioperative medicine in Australia.

Background: Health and medical research leads to improvements in healthcare globally. Identifying research priorities is important to researchers, funders, our patients, and other end users. This can ensure that the research is more broadly accepted and has greater impact.

Pelvic floor muscle training with feedback or biofeedback for urinary incontinence in women.

Background: Pelvic floor muscle training (PFMT), compared to no treatment, is effective for treating urinary incontinence (UI) in women. Feedback and biofeedback are additional resources that give women more information about their pelvic floor muscle contraction. The extra information could improve training performance by increasing capability or motivation for PFMT.

Adjuvanted subunit intranasal vaccine reduces SARS-CoV-2 onward transmission in hamsters.

Introduction: Most COVID-19 vaccine trials have focused on recipient protection, not protection of their contacts, a critical need. As a subunit intranasal COVID-19 vaccine reduced nasopharyngeal virus more than did an intramuscular (IM) vaccine, we hypothesized that this vaccine might reduce onward transmission to others.

Methods: We vaccinated hamsters with either the IM-administrated licensed mRNA vaccine twice or one dose of mRNA IM followed by adjuvanted subunit intranasal vaccine.

Communication partner training for aged-care workers: A scoping review.

Background: In aged-care settings, direct care staff play a crucial role in supporting older people with communication needs. Many direct care staff, however, have unmet skill needs in interpersonal, intercultural, and intergenerational communication. Communication Partner Training (CPT) provides a potential solution.

Intra-operative consultation: The benefits and optimization of asking for second surgical opinions.

Background: Intra-operative consultation (IOC) presents an opportunity for successful collaboration around direct patient care in an unanticipated fashion. Besides technical performance and cognitive guidance, successful IOC benefits from incorporating a blend of non-technical skills (NTS) such as communication, teamwork, and decision-making during the ideally supportive episode. Failure to use such skills may lead to untoward consequences for the surgeon who requests IOC despite successful patient rescue.

"I'm Never Gonna Go Back So I've Gotta Do It Forward": Exploring Posttraumatic Growth in Aphasia.

Purpose: The aim of this study was to explore posttraumatic growth (PTG) in people with aphasia.

Method: As part of a larger multisite study, 23 people with aphasia (12 females, 11 males) each completed a 60-min semistructured interview during which they expanded on previously given questionnaire responses and then answered five additional open-ended questions about communication in their daily life. Interviews were transcribed orthographically, coded using reflexive codebook analysis, and synthesized into themes and categories by team members that included a person with aphasia.

Priorities for post-stroke aphasia service development: Prioritisation phase of an experience-based co-design study.

Objective: Post-stroke aphasia (language impairment) has a devastating impact on quality of life and people with aphasia experience long-term unmet needs. A shared understanding of the experiences underpinning these unmet needs is required to identify priorities for improvement. Establishing priorities for meaningful service improvement requires involvement of service users and providers.

Physiological and molecular responses of the chorioallantoic membranes to diluted bitumen exposures in multiple bird species.

Embryotoxicity is a well-known consequence of polycyclic aromatic compound (PAC) exposure, but the molecular mechanisms of action of PAC mixtures, especially for unconventional crude petroleum types such as diluted bitumen (dilbit), remain to be fully elucidated in birds. To explore the mechanism of action of PAC in birds, the egg-injection model was used. Eggs of Domestic Chicken (Gallus gallus), Double-crested Cormorant (Nannopterum auritum), and Northern Gannet (Morus bassanus) were injected with 0.

Drinking water treatment residuals reduce toxicity to fish from metal-contaminated sediments.

Drinking water treatment residuals (DWTRs) produced as a result of the coagulation-flocculation process during water treatment are considered waste materials. Characterization of this material shows its ability to sequester metals and other anionic and cationic chemicals. Drinking water treatment residuals from two different drinking water treatment plants located in Wyoming and Oregon were evaluated for their ability to function as viable capping materials of metal-contaminated sediments.

A roadmap to implementing machine learning in healthcare: from concept to practice.

Background: The adoption of machine learning (ML) has been slow within the healthcare setting. We launched Pediatric Real-world Evaluative Data sciences for Clinical Transformation (PREDICT) at a pediatric hospital. Its goal was to develop, deploy, evaluate and maintain clinical ML models to improve pediatric patient outcomes using electronic health records data.

Forecasting interannual abundance of Helicoverpa zea (Lepidoptera: Noctuidae).

Corn earworm, Helicoverpa zea Boddie (Lepidoptera: Noctuidae), is a common herbivore that causes economic damage to agronomic and specialty crops across North America. The interannual abundance of H. zea is closely linked to climactic variables that influence overwintering survival, as well as within-season host plant availability that drives generational population increases.

Children with a tracheostomy: Global speech-language therapists' practice.

Purpose: Speech-language Therapists (SLTs) are specialists in communication, feeding and swallowing as core members of the paediatric tracheostomy multidisciplinary team (MDT). Inconsistent tracheostomy care leads to staff and family frustration and delayed intervention. Little is known about international SLT tracheostomy practices.

Caregiver perceptions of usual care home programs for persons with acquired brain injury: a qualitative descriptive study.

Objective: The study explores caregiver perceptions of home programs for clients with acquired brain injury based on current clinical care after transition to the community.

Design: A qualitative descriptive study.

Setting: Within the community, post inpatient rehabilitation.

Comparisons of approaches to pelvic floor muscle training for urinary incontinence in women.

Background: Pelvic floor muscle training (PFMT) is a recommended treatment for female stress, urgency, and mixed urinary incontinence. Training varies in exercise type (pelvic floor muscles contracting with and without other muscles), dose, and delivery (e.g.

A safe insect-based chikungunya fever vaccine affords rapid and durable protection in cynomolgus macaques.

Eilat (EILV)/chikungunya virus (CHIKV), an insect-based chimeric alphavirus was previously reported to protect mice months after a single dose vaccination. The underlying mechanisms of host protection are not clearly defined. Here, we assessed the capacity of EILV/CHIKV to induce quick and durable protection in cynomolgus macaques.

First detection of Bemisia tabaci (Hemiptera: Aleyrodidae) MED in Oklahoma and development of a high-resolution melting assay for MEAM1 and MED discrimination.

The sweetpotato whitefly, Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae), is a polyphagous pest recognized as composed of several cryptic or sibling species. The Middle East-Asia Minor 1 (MEAM1) and the Mediterranean (MED) putative species are invasive and destructive worldwide. The MEAM1 is established throughout the United States, while MED is documented in 27 states.

Impact of target-derived and ambient oxygen on gas-phase oxidation in laser ablation plumes.

Gas-phase oxidation in a laser-produced plasma is significantly influenced by the availability of oxygen in and around the plume. In this study, we investigate the role of target-derived and ambient oxygen on AlO formation in plasmas generated from aluminum (Al) and AlO targets in air and argon, respectively. Our results highlight that gas-phase oxidation occurs early during the evolution of AlO plasmas in argon, in contrast to Al plasmas in air, where the initial exclusion of oxygen from the plume delays the chemical reactions.

A comparison of handheld versus cart-based ultrasound in the evaluation and diagnosis of carpal tunnel syndrome.

Background: Carpal tunnel syndrome (CTS) is responsible for over 90 % of median nerve neuropathies. Though a clinical diagnosis, evaluation of nerve conduction via electrodiagnostic studies (EDX) and median nerve cross sectional area (CSA) through sonographic imaging provides supporting evidence and insight into disease severity. The advent of handheld ultrasound devices offers a portable, cost-effective and non-invasive method for median nerve assessment, yet its accuracy compared to traditional cart-based ultrasound has not been assessed in this setting.

Pain Following Obstetric Anal Sphincter Injuries: A Prospective Cohort Study.

Importance: Studies characterizing pain and pain management following obstetric anal sphincter injury (OASI) are limited.

Objectives: Our primary objective was to analyze time to pain resolution following OASI. Secondary objectives included analyzing pain severity, location, triggers, and patterns of pain medication use.

Cellular senescence in acute human infectious disease: a systematic review.

Introduction: This systematic review explores the relationship between cellular senescence, an age-related inflammatory phenomenon, with acute human infectious disease.

Methods: Embase via OVID, Scopus, Web of Science, Global Index Medicus, Cochrane Library via Wiley, and ClinicalTrials.gov were queried.

Evaluating the effect of hyperbaric oxygen therapy to treat mastectomy skin flap ischemia in breast reconstruction: A single-institution retrospective analysis.

Background: Mastectomy skin flap ischemia is a well-known postoperative complication following mastectomy and breast reconstruction. Hyperbaric oxygen therapy (HBOT) has shown promising results for reducing the adverse effects associated with mastectomy skin flap ischemia and associated necrosis; however, there is paucity of literature regarding the indications for HBOT following breast cancer surgery. This study aimed to assess HBOT efficacy in treating and mitigating complications from postoperative tissue ischemia.

Cultivating the future leaders of chemical biology.

The inaugural RSC Chemistry Biology Interface Community Leadership Retreat for Early Career Researchers aimed to provide a unique combination of research leadership training, discussion and collaboration opportunities to emerging chemical biologists from the UK and Europe. This article outlines the ethos and reports the outcomes from this new event for the Royal Society of Chemistry and future plans to establish this event as an ongoing feature in the chemical biology conference landscape.