Publications by authors named "Waliyde Jabeur"
Intensive chemotherapy followed by autologous stem cell transplantation in primary central nervous system lymphomas (PCNSLs). Therapeutic outcomes in real life-experience of the French Network.
Laurence Schenone Caroline Houillier Marie Laure Tanguy Sylvain Choquet Kossi Agbetiafa Waliyde Jabeur
Bone Marrow Transplant
June 2022
Article Synopsis
- * The study found that patients receiving treatment at first relapse and those treated with specific chemotherapy combinations faced poorer prognoses and higher treatment-related mortality, especially when SCAT was administered beyond the first relapse.
- * Overall survival rates were significant, with 5-year survival at 80% for first-line treatment and 50% for first-relapse treatment, indicating the importance of timing in ASCT to improve the benefit/risk ratio for different chemotherapy regimens.
Objective: The majority of patients with a familial cerebral small vessel disease (CSVD) referred for molecular screening do not show pathogenic variants in known genes. In this study, we aimed to identify novel CSVD causal genes.
Methods: We performed a gene-based collapsing test of rare protein-truncating variants identified in exome data of 258 unrelated CSVD patients of an ethnically matched control cohort and of 2 publicly available large-scale databases, gnomAD and TOPMed.