The Equal Neutralizing Effectiveness of BNT162b2, ChAdOx1 nCoV-19, and Sputnik V Vaccines in the Palestinian Population.

Since the beginning of the COVID-19 pandemic, different viral vector-based and mRNA vaccines directed against the SARS-CoV-2 "S" spike glycoprotein have been developed and have shown a good profile in terms of safety and efficacy. Nevertheless, an unbiased comparison of vaccination efficiency, including post-vaccination neutralizing activity, between the different vaccines remains largely unavailable. This study aimed to compare the efficacy of one mRNA (BNT162b2) and two non-replicating adenoviral vector vaccines (ChAdOx1 nCoV-19 and Sputnik V) in a cohort of 1120 vaccinated Palestinian individuals who received vaccines on an availability basis and which displayed a unique diversity of genetic characteristics.

Human Urinary Myiasis Caused by in Palestine: A Case Report.

In humans and other mammals, urinary myiasis can be rarely caused by , which belongs to the order Diptera. In this case, we report a 21-year-old woman with this myiasis. She was complaining of dysuria and bilateral Costolumbar pain.

Prevalence of and risk factors for Enterobius vermicularis infestation in preschool children, West Bank, Palestine, 2015.

Background: Enterobius vermicularis (pinworm) infestation is a common condition that primarily affects children.

Aims: The aim of this study was to assess the prevalence of and the risk factors for E. vermicularis infestation in preschool children in north West Bank.

Prevalence of SARS-CoV-2 antibodies in the Palestinian population: A primary health center-based cross-sectional study.

This study aimed to assess the prevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) total antibodies in the north, middle, and south regions of West Bank and the prevalence of SARS-CoV-2 specific antibodies (IgA, IgM, and IgG) in the Palestinian population. This was a cross-sectional study. The serological and epidemiological data of 1269 persons were assessed.

Early perception, behavior, knowledge, and preventive practices related to COVID-19 among Palestinians.

It is necessary to understand early perception, behavior, and knowledge of coronavirus disease 2019 (COVID-19) and preventive practices in relation to suggested policies and information accessible to the Palestinian population during the early stages of the pandemic. The aim of this research is to contribute to this understanding for the purpose of affecting future practical preventive policies that can be implemented and adapted in Palestine in order to shape a new reflective practices model to face any future epidemic crisis of any type. A cross-sectional design was used to conduct the study over 3 weeks in April 2020 and an online survey was disseminated in all areas of Palestine.

Knowledge, Perceptions, and Prevention Practices among Palestinian University Students during the COVID-19 Pandemic: A Questionnaire-Based Survey.

The purpose of this study is to offer a timely understanding of university students' knowledge, perception, and preventative practices related to COVID-19 in Palestine and to determine affecting factors (gender, region, and type of locality). A cross-sectional design was used and data was collected over 2 weeks in April 2020 through an online survey. A total of 484 surveys were collected from students from different Palestinian universities.

The Epidemiology of Anti-Sperm Antibodies Among Couples with Unexplained Infertility in North West Bank, Palestine.

Introduction: Anti sperm antibodies (ASA) can present in serum and semen and they may lead to impair the sperms function leading to infertility. The precise mechanism of generation of these antibodies is yet to be discovered.

Aim: This study was performed to determine the prevalence of anti-sperm antibodies (ASA) in patients with unexplained infertility.

Hypericum triquetrifolium-Derived Factors Downregulate the Production Levels of LPS-Induced Nitric Oxide and Tumor Necrosis Factor-α in THP-1 Cells.

Based on knowledge from traditional Arab herbal medicine, this in vitro study aims to examine the anti-inflammatory mechanism of Hypericum triquetrifolium by measuring the expression and release of pro-inflammatory cytokines, tumor necrosis factor-α (TNF-α) and interleukine-6 (IL-6), and inducible nitric oxide synthase (iNOS) in human monocytic cells, THP-1. The effects were assessed by measuring the levels of secretory proteins and mRNA of TNF-α and IL-6, the levels of nitric oxide (NO) secretion and the expression of iNOS in THP-1 cells. Cells were treated with 5 μg lipopolysaccharide/ml (LPS) in the presence and absence of increasing concentrations of extracts from the aerial parts of H.

Geldanamycin, a potent and specific inhibitor of Hsp90, inhibits gene expression and replication of human cytomegalovirus.

The effect of geldanamycin (GA), a specific inhibitor of heat shock protein 90 (Hsp90), on gene expression and replication of human cytomegalovirus (HCMV) was studied in human embryonic lung (HEL) fibroblasts. Kinetic analysis indicated that GA delayed synthesis of major immediate early (MIE), early and late viral proteins, and blocked a second tier of the synthesis of these proteins that occurred in untreated cells after 48 h post-infection (pi). Moreover, when HCMV-infected HEL cells were maintained with medium containing 40 nM GA for 6 days, with medium changes at 2-day intervals, the virus yield was reduced to an undetectable level.

A human papillomavirus type 16 vaccine by oral delivery of L1 protein.

To establish an edible HPV16 vaccine, we constructed a recombinant HPV16 L1-expressing Schizosaccharomyces pombe yeast strain (HPV16L1 yeast). A preliminary study revealed that freeze-dried yeast cells could be delivered safely, and were digested in the mouse intestine. The freeze-dried HPV16 L1 yeast was administered orally as an edible vaccine, with or without the mucosal adjuvant heat-labile toxin LT (R192G), to 18 female BALB/c mice.