Background: Osteopontin (OPN) has been postulated to have a role in several T-helper (Th) 1 and Th 17-mediated diseases including psoriasis (PS), through multiple mechanisms sharing in the onset and worsening of PS, OPN shares in induction of keratinocyte proliferation through inhibiting keratinocyte apoptosis, OPN acts as a proinflammatory agent that participates in the upregulation of Th cell lineages, among which are the Th 1 and Th 17 cells.
Aims And Objectives: The aim of this study was to explore the possible role of OPN in the pathogenesis of PS.
Materials And Methods: This case-control study was carried out on 18 patients of chronic plaque PS (mean age 37.