Publications by authors named "Waleed Minzel"
CKIα ablation induces p53 activation, and CKIα degradation underlies the therapeutic effect of lenalidomide in a pre-leukemia syndrome. Here we describe the development of CKIα inhibitors, which co-target the transcriptional kinases CDK7 and CDK9, thereby augmenting CKIα-induced p53 activation and its anti-leukemic activity. Oncogene-driving super-enhancers (SEs) are highly sensitive to CDK7/9 inhibition.
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- The enzyme COX-2 is crucial in the kidneys for producing angiotensin II (AngII), which then reduces COX-2 levels through the activation of the AT1 receptor.
- Research shows that the AT1 receptor not only negatively affects COX-2 indirectly but also directly decreases its levels by promoting its degradation via ubiquitination.
- A specific part of the AT1 receptor's structure is essential for this regulation, suggesting that targeting this mechanism could lead to new treatments for conditions linked to excess COX-2.
The enzyme cyclooxygenase-2 (COX-2) is rapidly and transiently up-regulated by a large variety of signals and implicated in pathologies such as inflammation and tumorigenesis. Although many signals cause COX-2 up-regulation, much less is known about mechanisms that actively down-regulate its expression. Here we show that the G protein-coupled receptor prostaglandin E(1) (EP(1)) reduces the expression of COX-2 in a concentration-dependent manner through a mechanism that does not require receptor activation.
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