Seasonal trends in antidepressant prescribing, depression, anxiety and self-harm in adolescents and young adults: an open cohort study using English primary care data.

Background: There is an increasing demand for mental health services for young people, which may vary across the year.

Objective: To determine whether there are seasonal patterns in primary care antidepressant prescribing and mental health issues in adolescents and young adults.

Methods: This cohort study used anonymised electronic health records from general practices in England contributing to QResearch.

Frequency and impact of medication reviews for people aged 65 years or above in UK primary care: an observational study using electronic health records.

Background: Medication reviews in primary care provide an opportunity to review and discuss the safety and appropriateness of a person's medicines. However, there is limited evidence about access to and the impact of routine medication reviews for older adults in the general population, particularly in the UK. We aimed to quantify the proportion of people aged 65 years and over with a medication review recorded in 2019 and describe changes in the numbers and types of medicines prescribed following a review.

Motorized Robotic Closed Cervical Traction: Biomechanical Proof of Concept.

Study Design: Biomechanical study.

Objective: To demonstrate that robotic cervical traction can apply closed cervical traction as effectively as manual weight-and-pulley traction in extension spring and cadaveric models.

Summary Of Background Data: Closed cervical traction is used to reduce subaxial cervical spine dislocation injuries and to distract the intervertebral space during cervical spine surgery.

Developing an Automated Assessment of In-session Patient Activation for Psychological Therapy: Codevelopment Approach.

Background: Patient activation is defined as a patient's confidence and perceived ability to manage their own health. Patient activation has been a consistent predictor of long-term health and care costs, particularly for people with multiple long-term health conditions. However, there is currently no means of measuring patient activation from what is said in health care consultations.

Exactly Marginal Deformations and Their Supergravity Duals.

We study the space of supersymmetric AdS_{5} solutions of type IIB supergravity corresponding to the conformal manifold of the dual N=1 conformal field theory. We show that the background geometry naturally encodes a generalized holomorphic structure, dual to the superpotential of the field theory, with the existence of the full solution following from a continuity argument. In particular, this work allows us to address the long-standing problem of finding the gravity dual of the generic N=1 deformations of N=4 conformal field theory: even if we are not able to give it in a fully explicit form, we provide a proof-of-existence of the supergravity solution.

An exploration of the experience of mental health service users when they decide they would like to change or withdraw from prescribed medications.

This paper reports on a collaborative research project initiated by service user representatives and led by clinicians from the mental health service in Derbyshire. The study explored the experiences of mental health service users when they either changed or terminated their use of mental health-related medications. Three focus groups were conducted with mental health service users from across the county.

Universal fermionic spectral functions from string theory.

We carry out the first holographic calculation of a fermionic response function for a strongly coupled d=3 system with an explicit D=10 or D=11 supergravity dual. By considering the supersymmetry current, we obtain a universal result applicable to all d=3 N=2 SCFTs with such duals. Surprisingly, the spectral function does not exhibit a Fermi surface, despite the fact that the system is at finite charge density.

Central charge of supersymmetric 5D anti-de sitter space solutions of type IIB supergravity.

We show that generic supersymmetric 5D anti-de Sitter solutions of type IIB supergravity admit a canonical contact structure. This structure determines the central charge of the dual field theory and the conformal dimension of operators dual to supersymmetric wrapped D3-branes. Hence both quantities can be calculated using incomplete information about the solutions, allowing us to prove that they are rational numbers for solutions with a U(1) R symmetry, in agreement with field theory expectations.

Supersymmetric 3D anti-de Sitter space solutions of type IIB supergravity.

For every positively curved Kähler-Einstein manifold in four dimensions, we construct an infinite family of supersymmetric solutions of type IIB supergravity. The solutions are warped products of AdS3 with a compact seven-dimensional manifold and have nonvanishing five-form flux. Via the anti-de Sitter/conformal field theory correspondence, the solutions are dual to two-dimensional conformal field theories with (0,2) supersymmetry.

Management of burned long bones.

The management of severely burned and exposed supportive osseous tissues is not fully standardized. We present two patients in whom extensive debridement and decortication of the involved bone may have contributed to subsequent stress fractures. We propose an alternative therapeutic approach for this problem, including: minimal debridement of the bone, early coverage of the exposed bone with vascularized muscle, and adequate prophylactic protection.