Is There a Link between Thyroid Peroxidase Gene Promoter Polymorphisms and Autoimmune Thyroiditis in the Polish Population?

(1) Autoimmune thyroiditis (AIT) is the most common cause of primary hypothyroidism and one of the most frequent organ-specific autoimmune diseases. Its pathogenesis is polygenic and still requires further research. The aim of the study was to assess, for the first time in the Caucasian population, the role of selected gene promoter polymorphisms (rs2071399 G/A, rs2071400C/T, rs2071402 A/G, and rs2071403 A/G) in the development of AIT.

The Comparison of Predictive Value Among Chemerin, IL-18 and Hormonal Parameters in Assessing the Risk of Metabolic Syndrome in Men.

Chemerin (CHEM) is a new proinflammatory adipokine involved in the immune, metabolic and reproductive processes. Low-grade state inflammation (LGSI) is a key element in the pathogenesis of metabolic syndrome (MS). Low SHBG is a good marker of male hypogonadism in MS.

Can Low SHBG Serum Concentration Be A Good Early Marker Of Male Hypogonadism In Metabolic Syndrome?

Introduction: In men suffering from metabolic syndrome, accompanying insulin resistance may result in a lowering of sex hormone-binding globulin (SHBG) plasma levels and cause changes in their androgenic status.

Aim: The objective of the research was to assess selected androgens and SHBG plasma levels in males meeting diagnostic criteria for MS compared to healthy males.

Patients And Methods: The group consisted of 65 men aged between 40 and 70 years old fitting IDF metabolic syndrome criteria and 84 controls.

Vitamin D Receptor Gene Polymorphisms and Autoimmune Thyroiditis: Are They Associated with Disease Occurrence and Its Features?

Purpose: Vitamin D, besides its role in calcium-phosphorus metabolism, turned out to play a significant immunomodulating function. Until now four single nucleotide polymorphisms of vitamin D receptor gene (), rs2228570 (I), rs1544410 (I), rs7975232 (I), and rs731236 (I), have been studied in autoimmune thyroid disorders, with conflicting results. Another functional polymorphism of the gene, rs11568820 (Cdx2), has been shown to influence the immune system, although it has not been studied for its association with autoimmune thyroiditis to date.

The reciprocal links between synaptophysin serum levels and the prevalence of metabolic syndrome according to selected low-grade inflammation indices and age-related androgen serum level changes in men.

Unlabelled: The correlations between synaptophysin (SYP) plasma levels and the brain neurotransmission activity are still not strictly identified. However, the efficiency of neurotransmission depends, inter alia, on the age, hormonal status, and coexistence of a low-grade systemic inflammation (LGSI) which is regarded as a pathogenic link with obesity and insulin resistance, atherogenesis and aging per se.

Aim: The aim of this study was to investigate the associations between synaptophysin serum levels and age, LGSI indices, homocysteine and selected hormonal parameters (dehydroepiandrosterone and its sulfate, free-testosterone, SHBG) and the prevalence of metabolic syndrome (MS) in men over the age of 40.

[Evaluation of relationships between plasma androgens level and clinical signs of hipoandrogenism according to age and comorbidity of metabolic syndrome in men].

Unlabelled: The prevalence of late-onset hipogonadism (LOH) in men is not accurately determined and may be overestimated. Androgen deficiency is causally linked to insulin resistance, regardless of age. Clinical signs of androgen deficiency are not uniquely specific for LOH.

[Evaluation of the relationships between plasma homocysteine level and selected low-grade inflammation indices according to the prevalence of metabolic syndrome in men].

Unlabelled: Metabolic syndrome (MS) is associated with low-grade systemic inflammation. Hyperhomocysteinemia is considered recently as a consequence of immune activation. Acute phase proteins, proinflammatory cytokines and probably homocysteine (hHcy) are involved in the pathogenesis of MS, atherosclerosis and ageing.

Assessment of selected serum inflammatory markers of acute phase response and their correlations with adrenal androgens and metabolic syndrome in a population of men over the age of 40.

Introduction: Inflammatory mechanisms and decreasing adrenal androgen production are involved in the pathogenesis of numerous age-related diseases.

Objectives: The aim of our study was to assess selected negative (transferrin) and positive (alpha1-antichymotrypsin [alpha1-ACT], C-reactive protein [CRP]) acute phase proteins, and to investigate associations between these proteins and serum dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) levels, as well as anthropometrical and biochemical indices of metabolic syndrome (MS) in men over 40 years of age.

Patients And Methods: In 271 randomly selected men aged 40 to 80 years and living in the province of Lubuskie, Poland, transferrin, alpha1-ACT, CRP, and adrenal androgens were measured and features of metabolic syndrome were evaluated.

[Could serum DHEA and DHEAS levels be good risk predictors of metabolic syndrome and osteoporosis in the population of ageing men?].

Unlabelled: The occurrence of metabolic syndrome (MS) and osteoporosis is essentials danger for public health. It seems that one of epidemiological factors of those diseases is age-depending adrenal androgens deficiency.

Aim Of The Study: was to evaluate relationships between DHEA/DHEAS serum levels and BMD along with frequency of MS in ageing Caucasian men.

[Thyroid gland and the aging process of the men].

Changes in the anatomy of thyroid and age-related modifications in the regulation of the hypothalamic-pituitary-thyroid axis in aging men were described and reciprocal dependences with the cytokine network were also discussed. Pathophysiological role of the inflammatory cytokines in the promotion of thyroid dysfunctions, autoimmunological including were demonstrated. The modulating impact of environmental factors (micronutrient deficiencies, condiments) on thyroid metabolism was reported.

[Current views on etiopathogenesis of aging].

Global aging of populations is demographic, sociologic and medical important phenomenon. In the paper a general demographic characteristic of aging in urbanized societies and a prognosis of changes were presented, Polish population including. Rate of aging is individual, but modified by environment factors.

[Could progeria be a model for the natural process of aging?].

Acceleration of ageing of urban populations causes the urgent need to carry out research in this area. One of the proposed models of investigation may be progeria. The most frequent syndromes of progeria and the way they are inherited were described.