The Kulunda Steppe in southwestern Siberia is one of the most intensely used agricultural landscapes in the world. Today it is characterized by depletive soil management practices and intensities that are unadapted to the local site conditions. Severe soil degradation and a loss of soil organic carbon (SOC) occurs at agriculturally used areas.
View Article and Find Full Text PDFChromosomal inversions occur in natural populations of many species, and may underlie reproductive isolation and local adaptation. Traditional methods of inversion discovery are labor-intensive and lack sensitivity. Here, we report the use of three-dimensional contact probabilities between genomic loci as assayed by chromosome-conformation capture sequencing (Hi-C) to detect multi-megabase polymorphic inversions in four barley genotypes.
View Article and Find Full Text PDFChromosome conformation capture sequencing (Hi-C) is a powerful method to comprehensively interrogate the three-dimensional positioning of chromatin in the nucleus. The development of Hi-C can be traced back to successive increases in the resolution and throughput of chromosome conformation capture (3C) ( Dekker , 2002 ). The basic workflow of 3C consists of (i) fixation of intact chromatin, usually by formaldehyde, (ii) cutting the fixed chromatin with a restriction enzyme, (iii) religation of sticky ends under diluted conditions to favor ligations between cross-linked fragments or those between random fragments and (iv) quantifying the number of ligations events between pairs of genomic loci (de Wit and de Laat, 2012).
View Article and Find Full Text PDFThis report describes three cases of bilateral macrophakia in 3-, 5-, and 9-year-old cats, respectively. All cats were presented because of visual deficits. Ophthalmic examination revealed macrophakia (the vitreous was replaced by the lens) and retinal changes (tapetal hyper-reflectivity, attenuation of retinal vessels, and retinal folds) in all cats.
View Article and Find Full Text PDFDiseases of the vitreous, fundus and optic nerve are described and illustrated according to their ophthalmological appearance. Vitreal alterations are commonly of developmental, degenerative, age related, traumatic or inflammatory origin and of minor clinical relevance. In contrast, those affecting the fundus, may be accompanied by visual deficits or blindness.
View Article and Find Full Text PDFObjective: Pimecrolimus is an ascomycin derivative that interferes selectively with the activation of T cells and mast cells and inhibits the production of inflammatory cytokines. This study evaluated the efficacy of an experimental ophthalmic formulation of pimecrolimus in treating keratoconjunctivitis sicca (KCS) and chronic superficial keratitis (CSK) in dogs. ANIMALS AND PROCEDURES: Eight dogs with KCS and six with CSK were included.
View Article and Find Full Text PDFTierarztl Prax
January 1997
Mother and son of a Yorkshire Terrier family showed excessive multifocal retinal dysplasia (RD1) and geographical retinal dysplasia (RD2), intra- and preretinal hemorrhages partial and total retinal detachment (total RD/RD3), residues of the pupillary membrane and as a newness in this combination a geographical, subepithelial corneal opacity, composed of small dots. One, not examined son of the same litter was congenitally blind. Similar corneal opacities were also found in two Rough Collies affected with CEA, RD, and microphthalmia, a young German Wirehair Pointer with primary absolute glaucoma in conjunction with goniodysplasia and RD in the healthy seeming fellow eye as well as in a poodle puppy affected with bilateral posterior suture-line cataract in connection with persistent primary hyperplastic vitreous (PHPV) in one and a globe-shaped deformed retina in connection with a persistent, blood conducting hyaloid artery in the other eye.
View Article and Find Full Text PDFTierarztl Prax
April 1996
Primary glaucoma was diagnosed in a five- and a six-year-old female German Hunting Terrier and a four-year-old female Wirehaired Foxterrier. The five-year-old Hunting Terrier had an absolute glaucoma in the right eye. The left eye showed a dysplastic pectinate ligament (DLP) and a narrow iridocorneal angle.
View Article and Find Full Text PDFIn the paper presented, the histological findings in four cats with glaucoma are reported by means of HE-stained paraffin embedded sections. To each case a clinical anamnesis is given. The authors describe primary glaucomas as well as secondary glaucomas of different aetiology.
View Article and Find Full Text PDFUsing a new model of a reversible pancreatic fistula which allows the long-term-investigation under nearly physiological conditions on the unrestrained dog, we tested the effect of somatostatin (50 micrograms), calcitonin (4 micrograms), glucagon (1 microgram), and prostaglandin E1 (150 micrograms) on the exocrine pancreatic function in 45 experiments over a period of 13 h: SST inhibits the basal as well as the secretin or CCK-stimulated secretion: calcitonin shows inhibition of the stimulated secretion only; glucagon blocks the secretin-stimulated pancreatic function; and PGE1 reduces the bicarbonate concentration and trypsin output in secretin stimulation, but in one of the two series it stimulates the basal secretion.
View Article and Find Full Text PDFZentralbl Veterinarmed A
February 1980
Chir Forum Exp Klin Forsch
September 1979
A new model of a reversible long-term pancreatic fistula was used on an alert, unrestrained dog to test the effect of four substances of the GEP system on the exocrine pancreatic function. The results indicate that SST significantly inhibits not only the basal secretion but also the stimulated secretion of volume, bicarbonate, and trypsine. Calcitonine inhibits only the stimulated secretion whereas PGE1 inhibits only the secretin-stimulated output of trypsine.
View Article and Find Full Text PDFOn the basis of the literature and of their own investigations, including animal experimentation, the authors attempt to show the possible causes of death following lightning strokes. Animal experiments give evidence of the important role of cardiac arrhythmias, in particular of asystolia and ventricular fibrillation. Cardiac arrest, respiratory standstill, burns, fractures, mechanical lesions of internal organs and hemorrhages are stated as causes of death.
View Article and Find Full Text PDFTierarztl Prax
December 1977