Study on peripheral antinociception induced by hydrogen peroxide (HO): characterization and mechanisms.

The present study aimed to evaluate the possible peripheral HO-induced antinociception and determine the involvement of opioidergic, cannabinoidergic and nitrergic systems, besides potassium channels in its antinociceptive effect. Prostaglandin E was used to induce hyperalgesia in male Swiss mice using the mechanical paw pressure test. HO (0.