Publications by authors named "Walaa S Nazim"
Article Synopsis
- - The study developed a vitamin D-loaded nanoemulsion (VD3-NE) to enhance the oral bioavailability of vitamin D for autistic children, utilizing various vegetable oils and emulsifiers to create eight formulations.
- - The best formulation, VD3-NE6, showed high drug content, stable droplet size, and maintained safety over three months in rats, without causing toxic effects or impacting kidney and liver functions.
- - VD3-NE6 demonstrated significantly improved oral bioavailability compared to plain vitamin D, suggesting its potential effectiveness in managing vitamin D deficiency in autistic children.
Purpose: Obesity is more prevalent among people with Down Syndrome (DS) compared to general population. In this pilot study, we investigated the effect of cystathionine beta-synthase (CBS) overdosage on the regulation of transsulfuration pathway and the obesity phenotype in fifty adolescents (25 obese/overweight and 25 lean) with trisomy 21.
Methods: The transcriptional levels of in leukocytes and its translational levels in plasma were quantified using real time polymerase chain reaction and enzyme-linked immunosorbent assay respectively.
Background: Undegraded glycosaminoglycans (GAGs) induced by deficiency of enzymes are the primary cause of mucopolyscchardoses. Mucopolysacchardoses (MPS) are a group of rare lysosomal storage diseases (LSD). The quantification of a specific enzymatic activity is needed for accurate diagnosis.
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