Publications by authors named "Walaa Mohamed Sarhan"

Background: Obesity is a multifactorial metabolic disease resulting from behavioral and genetic factors. Obesity is linked to diabetes mellitus and hypertension, which are considered as major risk factors for chronic kidney disease (CKD); moreover, it has a direct effect on developing CKD and end stage renal disease (ESRD). Here was aimed to examine the association between uncoupling protein 2 (UCP2) gene expression and obesity in CKD patients.

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Gene conversion is a process of transferring genetic material from one homologous sequence to another. Most reported gene conversions are meiotic although mitotic gene conversion is also described. When using CRISPR/Cas9 to target the human hemoglobin subunit beta (HBB) gene, hemoglobin subunit delta (HBD) gene footprints were observed in HBB gene.

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The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) system discovered using bacteria has been repurposed for genome editing in human cells. Transient expression of the editor proteins (e.g.

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Synopsis of recent research by authors named "Walaa Mohamed Sarhan"

  • - Walaa Mohamed Sarhan's research primarily focuses on molecular biology techniques, particularly the application of CRISPR/Cas9 technology for genome editing in human cells and its implications for gene conversion processes.
  • - One notable study examined the role of uncoupling protein 2 (UCP2) gene expression in obesity among chronic kidney disease (CKD) patients, highlighting the interrelation between metabolic disorders and kidney health.
  • - Sarhan's work also includes innovative methodologies for delivering genetic editing tools, such as SaCas9 mRNA via lentivirus-like bionanoparticles, enhancing the efficiency and effectiveness of targeted genome modifications.