Proprioceptive neuromuscular facilitation stretching exercises for treatment of temporomandibular dysfunction in patients with forward head posture: A double-blinded, randomized, controlled trial.

Background: Proprioceptive neuromuscular facilitation (PNF) stretching exercises have been widely advocated for the management of patients with different musculoskeletal conditions. However, its effect on the treatment of temporomandibular dysfunction (TMD) in patients with forward head posture (FHP) has not been fully investigated.

Objective: To investigate the effect of PNF stretching exercises on the treatment of TMD in patients with FHP.

Pumpkin seeds (Cucurbita pepo subsp. ovifera) decoction promotes Trichinella spiralis expulsion during intestinal phase via "Weep and Sweep" mechanism.

Trichinosis is a zoonotic disease of communal health concern as it instigated human outbreaks in several countries. Besides, the development of resistance, traditional therapy has numerous antagonistic effects. Thereby, finding efficient natural alternatives is required.

Letrozole clomiphene citrate in Sudanese patients with infertility secondary to polycystic ovary syndrome.

Unlabelled: PCOS is a cluster of metabolic, hormonal, and environmental factors coupled with infertility in patients within reproductive age. This cross-sectional study compared letrozole (LTZ) Clomiphene citrate (CC) as ovulation inducers in infertile Sudanese patients with PCOS. Follicles ≥18 mm and pregnancy tests were used for comparison.

Collagen Fibril Orientation Instructs Fibroblast Differentiation Via Cell Contractility.

Collagen alignment is one of the key microarchitectural signatures of many pathological conditions, including scarring and fibrosis. Investigating how collagen alignment modulates cellular functions will pave the way for understanding tissue scarring and regeneration and new therapeutic strategies. However, current approaches for the fabrication of three-dimensional (3D) aligned collagen matrices are low-throughput and require special devices.

Assessment of Ismailia Canal for irrigation purposes by water quality indices.

Ismailia Canal is one of the significant streams of the Nile River in Egypt. The study aimed to determine the water quality of Ismailia Canal based on the regional and seasonal variability of physicochemical parameters, irrigation criteria, and the irrigation water quality index (IWQI). It was observed that the physicochemical parameters were within the acceptable FAO irrigation limits.

Evaluation of room temperature (30°C to 35°C) lyophilized vaccine with radio inactivated whole cells isolated from infected sheep.

Background And Aim: Vaccines are one of the important tools for fighting diseases and limiting their spread. The development of vaccines with high efficacy against diseases is essential. Ionizing radiation is the method used for the preparation of the irradiated gamma vaccine.

3D in vitro M2 macrophage model to mimic modulation of tissue repair.

Distinct anti-inflammatory macrophage (M2) subtypes, namely M2a and M2c, are reported to modulate the tissue repair process tightly and chronologically by modulating fibroblast differentiation state and functions. To establish a well-defined three-dimensional (3D) cell culture model to mimic the tissue repair process, we utilized THP-1 human monocytic cells and a 3D collagen matrix as a biomimetic tissue model. THP-1 cells were differentiated into macrophages, and activated using IL-4/IL-13 (M) and IL-10 (M).

Genetic Diversity in Casein Gene Cluster in a Dromedary Camel () Population from the United Arab Emirates.

Genetic polymorphisms, causing variation in casein genes (, , , and , have been extensively studied in goats and cows, but there are only few studies reported in camels. Therefore, we aimed to identify alleles with functional roles in the United Arab Emirates dromedary camel ( population to complement previous studies conducted on the same species. Using targeted next-generation sequencing, we sequenced all genes in the casein gene cluster in 93 female camels to identify and characterize novel gene variants.

Biomimetic 3D Models for Investigating the Role of Monocytes and Macrophages in Atherosclerosis.

Atherosclerosis, the inflammation of artery walls due to the accumulation of lipids, is the most common underlying cause for cardiovascular diseases. Monocytes and macrophages are major cells that contribute to the initiation and progression of atherosclerotic plaques. During this process, an accumulation of LDL-laden macrophages (foam cells) and an alteration in the extracellular matrix (ECM) organization leads to a local vessel stiffening.

Mitochondrial mutations in non-syndromic hearing loss at UAE.

Introduction: Hearing loss (HL) is a common sensory disorder over the world, and it has been estimated that genetic etiology is involved in more than 50% of the cases in developed countries. Both nuclear and mitochondrial genes were reported as responsible for hereditary HL. Mitochondrial mutations leading to HL have so far been reported in the MT-RNR1 gene, mitochondrially encoded 12S rRNA.

Dendritic cell immune potency on 2D and in 3D collagen matrices.

Dendritic cells (DCs) are antigen-presenting cells capable of either activating the immune response or inducing and maintaining immune tolerance. Understanding how biophysical properties affect DC behaviors will provide insight into the biology of a DC and its applications. In this work, we studied how cell culture dimensionality (two-dimensional (2D) and three-dimensional (3D)), and matrix density of 3D collagen matrices modulate differentiation and functions of DCs.

Artificial Biosystem for Modulation of Interactions between Antigen-Presenting Cells and T Cells.

T cell activation is triggered by signal molecules on the surface of antigen-presenting cells (APC) and subsequent exertion of cellular forces. Deciphering the biomechanical and biochemical signals in this complex process is of interest and will contribute to an improvement in immunotherapy strategies. To address underlying questions, coculture and biomimetic models are established.

Collagen Fibril Density Modulates Macrophage Activation and Cellular Functions during Tissue Repair.

Monocytes circulate in the bloodstream, extravasate into the tissue and differentiate into specific macrophage phenotypes to fulfill the immunological needs of tissues. During the tissue repair process, tissue density transits from loose to dense tissue. However, little is known on how changes in tissue density affects macrophage activation and their cellular functions.

Application of statistical response surface methodology for optimization of fluoride removal efficiency by Padina sp. alga.

Human exposure to fluoride in drink water at a level above 1.5 mg/L causes a lot of health problems. The present study was carried out to assess the fluoride biosorption capability of Padina sp.

A Novel Nonsense Mutation (c.414G>A; p.Trp138*) in Causes Hearing Loss in Yemeni Families: A Case Report.

Non-syndromic hearing loss (NSHL) is a hereditary disorder that affects many populations. Many genes are involved in NSHL and the mutational load of these genes often differs among ethnic groups. Claudin-14 (), a tight junction protein, is known to be associated with NSHL in many populations.

Safety and outcome of treatment of metastatic melanoma using 3-bromopyruvate: a concise literature review and case study.

3-Bromopyruvate (3BP) is a new, promising anticancer alkylating agent with several notable functions. In addition to inhibiting key glycolysis enzymes including hexokinase II and lactate dehydrogenase (LDH), 3BP also selectively inhibits mitochondrial oxidative phosphorylation, angiogenesis, and energy production in cancer cells. Moreover, 3BP induces hydrogen peroxide generation in cancer cells (oxidative stress effect) and competes with the LDH substrates pyruvate and lactate.