Publications by authors named "Walaa Fouad"
Article Synopsis
- Knee osteoarthritis (KOA) is a major global disability issue, and the study aimed to explore the link between the ADAMTS14 gene polymorphism and KOA, along with associated risk factors.
- A case-control study involving 158 KOA patients and 120 matched controls showed a significant difference in ADAMTS14 gene rs4747096 allele frequencies, with certain genotypes (AA and AG) linked to increased KOA risk.
- Key risk factors identified include age over 50, obesity, prolonged standing at work, and the recessive inheritance pattern of the A allele, indicating a need for further research on the genetic influence on KOA development.
Background: Irritable bowel syndrome (IBS) is one of the most prevalent functional gastrointestinal disorders. Medical students tend to report a higher prevalence of IBS since they are under constant stress. Many psychological difficulties are associated with IBS.
View Article and Find Full Text PDFA diverse population of fungi colonizes human hair and skin due to millions of years of functional integration and mutual adaptation. The human body, with its fungal communities, forms a complex entity. Microbial imbalance is promoted by instabilities in the host-mycobiota interaction system, which can be related to the development of various diseases.
View Article and Find Full Text PDFOver 296 million people are estimated to have chronic hepatitis B viral infection (CHB), and it poses unique challenges for elimination. CHB is the result of hepatitis B virus (HBV)-specific immune tolerance and the presence of covalently closed circular DNA as mini chromosome inside the nucleus and the integrated HBV. Serum hepatitis B core-related antigen is the best surrogate marker for intrahepatic covalently closed circular DNA.
View Article and Find Full Text PDFBackground: Critically ill COVID-19 patients are highly susceptible to opportunistic fungal infection due to many factors, including virus-induced immune dysregulation, host-related comorbidities, overuse and misuse of antibiotics or corticosteroids, immune modulator drugs, and the emergencies caused by the pandemic. This study aimed to assess the incidence, identify the potential risk factors, and examine the impact of fungal coinfection on the outcomes of COVID-19 patients admitted to the intensive care unit (ICU).
Methods: A prospective cohort study including 253 critically ill COVID-19 patients aged 18 years or older admitted to the isolation ICU of Zagazig University Hospitals over a 4-month period from May 2021 to August 2021 was conducted.
Aim: Assessing impact of lifestyle modification on Type 2 diabetes mellitus (T2DM) glycemic control and cognitive function.
Subjects & Methods: Prospective study was conducted on T2DM patients (92 patients as interventional group and 92 patients conventional therapy).
Results: After 6 months, significant improvements of HbA1c, oxidant and antioxidant, lipid profile, and cognitive function among only the interventional group (p < 0.
Article Synopsis
- Hepatitis C virus (HCV) chronic infection can lead to severe liver diseases, and in the Middle East, genotype 4 is the most common strain, impacting treatment effectiveness.
- * A study involving 200 patients in Saudi Arabia found that 97.5% achieved a sustained virologic response (SVR12) after treatment with direct-acting antiviral drugs (DAAs), with no significant response differences based on age, gender, or HCV genotype.
- * However, the presence of cirrhosis and gender were identified as independent factors that could negatively influence reaching the SVR12 outcome.
Hepatitis C virus (HCV) is a common cause of liver disease and is associated with various extrahepatic manifestations (EHMs). This mini-review outlines the currently available treatments for HCV infection and their prognostic effect on hepatic manifestations and EHMs. Direct-acting antiviral (DAA) regimens are considered pan-genotypic as they achieve a sustained virological response (SVR) > 85% after 12 wk through all the major HCV genotypes, with high percentages of SVR even in advanced fibrosis and cirrhosis.
View Article and Find Full Text PDFObjectives: We sought to assess the prevalence of hepatitis B virus (HBV) seroprotection among vaccinated children in the Assiut governorate, Egypt, and assess a booster dose immune memory response among non-seroprotected children.
Methods: Using a multistage cluster sample, 566 children were recruited from three clusters: one urban and two rural. Children were aged from nine months to 16 years old.
Objectives: To assess the potential value of some miRNAs as diagnostic biomarkers for mild cognitive impairment (MCI) among patients with type2 diabetes mellitus (T2DM) and to identify other risk factors for MCI among them.
Methods: This study enrolled 163 adults with T2DM using face to face interview. Cognitive function with its domains was assessed using Adenbrooke's Cognitive Examination III (ACE III).
Relation of Asthma Control with Quality of Life among a Sample of Egyptian Asthmatic School Children.
Open Access Maced J Med Sci
September 2019
Background: Asthma is considered a chronic health illness that not only resulted in physical symptoms but also emotional effects. It is; therefore, so important to assess the quality of life of asthmatic patients besides their level of disease control.
Aim: To determine the correlation of asthma control with the health-related quality of life (HRQOL) of asthmatic children in Egypt.
Objective: To evaluate early and long term anamnestic response to a booster dose of HBV vaccine among non-seroprotected children.
Subjects And Method: A national community based project was carried out on 3600 children aged 9 months to 16 years, fully vaccinated during infancy. They were recruited from 6 governorates representing Egypt.