STAT3 is involved in IL-6-Mediated Downregulation of Hepatic Transporters in Mice.

Unlabelled: Interleukin (IL)-6 decreases hepatic expression of numerous transporters. Although IL-6 signaling occurs through STAT3, the extent of the involvement of the STAT3 signaling pathway has not been elucidated.

Purpose: Our objective was to investigate whether IL-6-mediated effects occur through STAT3, and whether PXR plays a role in this regulation.