Development and validation of MyCommunication-Adults, a self-report communicative participation measure.

Background: People with communication problems experience challenges in participation. Optimizing communicative participation for this population is an important outcome of speech and language therapy. Participation experiences are best assessed from the patient's perspective, using a patient-reported outcome measure (PROM).

Azolla cultivation enables phosphate extraction from inundated former agricultural soils.

To combat the global loss of wetlands and their essential functions, the restoration and creation of wetlands is imperative. However, wetland development is challenging when soils have been in prolonged agricultural use, often resulting in a substantial nutrient legacy, especially of phosphorous (P). Inundating these soils typically leads to P mobilization, resulting in poor water quality and low biodiversity recovery.

Further development in measuring communicative participation: identifying items to extend the applicability of the communicative participation item bank.

Background: The ability to communicate is a prerequisite for participation in today's society. To measure participation in adults with communication disorders, the Communicative Participation Item Bank (CPIB) was developed in 2006. Since then, several new PROMs have been developed to measure communication and the impact of communication disorders on participation.

Everyday Barriers in Communicative Participation According to People With Communication Problems.

Purpose: The purpose of this study was to gain a comprehensive understanding of participation situations that are challenging for people with communication problems, to provide input for the further development of potential items for the Communicative Participation Item Bank (CPIB).

Method: A purposive sampling strategy was used to include a diverse group of people with communication problems. Diaries were used as a sensitizing exercise for inductive in-depth interviews.

Speech language therapists' experiences with subjective well-being in people with aphasia.

Background: Subjective well-being (SWB) and quality of life (QOL) are intricately related constructs. Recent research shows both constructs share some facets, but are distinct entities. It is unclear, both internationally and in the Netherlands, if and how SLTs address SWB in clinical practice.

Psychometric properties of the Dutch SAQOL-39NL in a generic stroke population.

Background: The psychometric properties of the Dutch version of the Stroke and Aphasia Quality Of Life-scale (SAQOL-39NL) have previously been assessed for people with aphasia after stroke, but not yet for stroke survivors without aphasia.

Objective: The objective is to evaluate the psychometric properties of the SAQOL-39NL in a stroke sample with and without aphasia.

Methods: The SAQOL-39NL was administered to survivors of stroke (N = 141) who received rehabilitation in specialized rehabilitation facilities, 3 and 6 months after the start of rehabilitation.

Profile of CD4 counts and symptoms in HIV positive patients on and not on antiretroviral therapy.

This communication pertains to a study on analysis of the profile of CD4 counts and symptoms in HIV infected adult subjects on and not on antiretroviral therapy. Clinical symptoms in HIV infected patients attending a tertiary care hospital in north India were recorded by direct questioning. Differences in distribution of categorical variables were analyzed using chi-square test.

A peculiar case of HIV transmission within a family in north India.

We describe an unusual case of heterosexual HIV transmission between two brothers within a family, due to a locally prevalent social custom of remarriage of the elder brother's widow, to the younger brother. This case of HIV secondary transmission, which could possibly have been stopped at certain points by better understanding and awareness about HIV transmission emphasizes the need for extensive post-test counselling of affected individuals and their family members.

Operationalizing integrated care on a clinical level: the INTERMED project.

During the last 10 years the INTERMED method has been developed as a generic method for the assessment of bio-psychosocial health risks and health needs and for planning of integrated treatment. The INTERMED has been conceptualized to counteract divisions and fragmentation of medical care. Designed to enhance the communication between patients and the health providers as well as between different professions and disciplines, the INTERMED is a visualized, action-oriented decision-support tool.

Extinction time and age of an allele in a large finite population.

For a single locus with two alleles we study the expected extinction and fixation times of the alleles under the influence of selection and genetic drift. Using a diffusion model we derive asymptotic approximations for these expected exit times for large populations. We consider the case where the fitness of the heterozygote is in between the fitnesses of the homozygotes (incomplete dominance).

Effect of iron chelators on paraquat toxicity in rats and alveolar type II cells.

There is general agreement that the lung damage seen in paraquat poisoning is due to the generation of free radicals in alveolar epithelial cells. We have recently shown that the iron chelator and antioxidant deferoxamine (DF) reduces the mortality caused by paraquat in vitamin-E-deficient rats. In the present study we investigated the effect of DF and the lipid soluble iron chelator compound 51 (CP51) of the hydroxypyridin-4-one family on paraquat poisoning in rats with a normal vitamin E status and on isolated alveolar type II cells (ATTC).

Mechanism of protection of alveolar type II cells against paraquat-induced cytotoxicity by deferoxamine.

Paraquat toxicity has been associated with the generation of free radicals in alveolar epithelial cells in which paraquat specifically accumulates via a polyamine uptake system. In the present study we investigated whether deferoxamine (DF), an iron chelator that has antioxidant capacity and that also has a polyamine-like structure, could protect alveolar type II cells (ATTC) against injury by paraquat. Radiolabeled [3H]adenine ATTC were incubated in a medium containing 75 microM paraquat in the absence or presence of DF (500 microM).

A rapid and sensitive micro-assay to determine the capacity of quinones to undergo redox cycling.

Using a series of aziridinyl-benzoquinones it is shown that the conversion of oxyhemoglobin to methemoglobin in sheep erythrocytes is correlated with the capacity of each quinone to undergo redox cycling. Based on these findings a semiquantitative assay is developed for the rapid screening of redox cycling quinones.

Continuous intravenous infusion of deferoxamine reduces mortality by paraquat in vitamin E-deficient rats.

Paraquat, an oxygen radical-generating agent, is a widely used agrochemical that is also toxic for humans, in whom it may cause respiratory failure. In the present study, we investigated the effect of deferoxamine (DF), an iron chelator with antioxidant capacity, on paraquat toxicity in vitamin E-deficient rats. After the administration of paraquat at a dose of 20 mg/kg the animals were treated with a continuous intravenous infusion of DF for 14 days.

Morphometric study of pseudoepitheliomatous hyperplasia in granular cell tumors of the tongue.

Several reports have mentioned the possibility of misdiagnosing pseudoepitheliomatous hyperplasia (PEH) of the overlying mucosa of a granular cell tumor as a squamous cell carcinoma (SCC). Because of this, morphometry was applied to five granular cell tumors with PEH and five well-differentiated SCC of the tongue. In addition, ten normal tongues have been examined.

Geographic stomatitis and psoriasis.

5 new cases of geographic stomatitis are presented and added to a review of 32 similar cases reported in the literature up to 1987. Furthermore, a series of 70 consecutive patients with psoriasis were examined for oral mucosal lesions. Based upon the findings of the literature and the results of the present study, there seems insufficient proof to consider geographic stomatitis an oral manifestation of psoriasis.

Osteoma or chondroma of the tongue; a clinical and postmortem study.

The occurrence of an osteoma or chondroma in the soft tissues of the oral cavity is rather uncommon. This anomaly occurs mainly on the tongue. Less than 60 cases have been published in the literature.

Thyroglossal cysts in patients over 30 years of age.

8 patients over 30 years of age with a thyroglossal cyst, who had not been operated on before and who underwent excision of the cyst by a Sistrunk procedure, are described. In 8 additional patients, a wait-and-see policy was adopted. Follow-up data of these 16 patients are reported 1.

Psychological aspects of patients with burning mouth syndrome.

This article reports the results of a psychological questionnaire survey of 184 patients who have burning mouth syndrome. The results are compared with normative data obtained in the Netherlands. In general, it may be concluded that in a large number of patients with glossodynia, psychological aspects such as anxiety, depression, and neurotic tendencies are of great importance.

Lingual thyroid. A clinical and postmortem study.

3 patients with lingual thyroid are reported. In addition, 5 patients are described with hypothyroidism in whom functioning thyroid tissue was only present at the base of the tongue without any noticeable swelling. In a postmortem study of 120 tongues, not a single case of lingual thyroid was encountered.

Extrahypothalamic vasopressin and oxytocin in the human brain; presence of vasopressin cells in the bed nucleus of the stria terminalis.

In the present study, the distribution of extrahypothalamic vasopressin (VP) and oxytocin (OXT) in the human brain was investigated by means of immunocytochemistry. In the septum verum, few VP fibers were found in the nucleus septalis lateralis and medialis (NSL and NSM), and in the bed nucleus of the anterior commissure. Very few VP and OXT fibers were present in the amygdala and in the hippocampus, mainly around the rostral tip of the lateral ventricle on the level of the pes hippocampi.

Candida albicans in median rhomboid glossitis. A postmortem study.

To investigate the possible rôle of Candida in median rhomboid glossitis, the presence of Candida was looked for both in the foramen cecum area and the lateral borders of 100 human cadaver tongues. Almost equal %s were found in both locations. Although extrapolation of findings from postmortem material to normal subjects is somewhat hazardous, the results seem to question the importance of Candida in the etiology of median rhomboid glossitis.

Amyloidosis of the tongue: a clinical and postmortem study.

Based on the limited number of reports and our own experience, amyloid involvement of the oral tissues seems to be rather rare, the tongue apparently being the most favoured site. Three such patients have been described in the present treatise. All 3 patients proved to be suffering from multiple myeloma or its prestage.