Incorporation of exemestane into ternary nanosponge system for enhanced anti-tumor potential in breast cancer.

The present investigation reports the potential of exemestane loaded cyclodextrin based nanosponges for the treatment of breast cancer. Fourier transform infrared, and nuclear magnetic resonance (NMR) spectroscopic analysis confirmed the encapsulation of ring B, C, and D of exemestane in the nanosponge cavity. studies demonstrated a 6.

High-resolution liquid chromatography mass spectrometry (HR-LCMS) and H NMR analysis of methanol extracts from marine seaweed .

A wide variety of bioactive secondary metabolites that seaweeds are claimed to generate can be used by the pharmaceutical industry to create novel medications. The primary goal of the current study was to use the HR-LCMS and NMR approach to analyse the phytochemical content of a methanolic extract of . The HR-LCMS and NMR analysis reveals the presence of bioactive compounds (amino acid, fatty acid, triterpenoids, carotenoid, aromatic compounds, flavonoids, secondary alcohols, diterpenes, lipid, phenolic compounds, sesquiterpenoids, quinolizidine alkaloid, and benzoquinone).

High-resolution liquid chromatography and mass spectrometry (HR-LCMS) assisted phytochemical profiling and an assessment of anticancer activities of and using and molecular docking analysis.

Marine algae's, owing to diverse range of secondary metabolites, opening up the new avenues in new drug development and can be used efficiently in anticancer research. Two seaweeds and are subjected to phytochemical investigation by HR-LCMS and NMR which confirms presence of different bioactive compounds. The cytotoxicity of the dichloromethane (DCM) fraction of and was determined using an methyl thiazolyl tetrazolium (MTT) test and showed considerable dose-dependent cytotoxicity on tumour cell lines.

Cyclodextrin Based Nanosponges: A Multidimensional Drug Delivery System and its Biomedical Applications.

Cyclodextrin based nanosponges are the designed nanocarriers for the projected delivery of complex drugs. They are multifunctional hypercrosslinked cyclodextrin polymers connected in a three-dimensional, mesh-like network. Their functional characteristics can be fabricated by using different crosslinkers or their different rations with polymer.

Ethanolic extract of Linn. ameliorates diabetes-associated complications in alloxan-induced diabetic rats.

Background: The aim of this study was to evaluate the hypoglycemic, hypolipidemic, and anti-inflammatory potentials of ethanolic extract of leaves of linn. (EEAP) on alloxan-induced diabetic rats scientifically. Hyperglycemia induces the generation of free radicals which can affect antioxidant defenses, thus leading to the disruption of beta cellular functions, oxidative damage to membranes, leading to the release of C-reactive protein and altered lipid metabolism.

Noninvasive cellular internalization of silver molecules by chitosan nanoneedles: a novel nanocarrier.

We explore with molecular modeling, dynamics simulations, and a statistical model the ability of chitosan nanoneedles (CNNs) to be internalized into a model lipid bilayer as a function of their length, keeping in view of their applications in the field of biomedicine for advanced targeted drug delivery. In this study, we have computationally modeled and studied the structural geometry and the stability of CNNs formed by 4, 6, and 8 subunits. We reported the molecular surface analysis of the modeled CNNs along with molecular dynamic (MD) simulations studies toward revealing the noninvasive cellular internalization potential of these CNNs and a case study has been carried to study the ability of CNNs to translocate silver nanoparticles across membrane.