[Manifestation of glutathione S-transferase GSTM1 and GSTT1 in female patients with bleomycin-positive chromosome instability].

Objectives: The purpose of this research is to assess the incidence of gene polymorphisms coding the GSTM1 and GSTT1 enzymes in a population of female patients with chromosome instability.

Materials And Methods: The PCR method was used to determine the genotype for GSTM1 and GSTT1. The breaks per cell and the percentage of damaged cells were calculated.

[Analysis of clinical usefulness of the cytologic smear results for pregnant women using the Bethesda system].

The aim of this paper was to analyse the clinical usefulness of cytological smear results for pregnant women by use of Bethesda system. The examinations were carried for 5 years and correct results of cytological assays were achieved from 3265 patients. Low and high grade squamous intraepithelial cells were reported in 4.

Function of insulin-like growth factor (IGF-I) and its binding protein (IGFBP-1) in pathological proliferation of endometrium.

The purpose of this project was the investigation of insulin, IGF-I and IGFBP-1 concentrations in the serum of patients with pathological changes in endometrium. IGF-I and its binding protein (IGFBP-1) stimulate cell growth and differentiation of the normal and neoplastic endometrium. The mean values of IGF-I concentrations in the group of patients with atypical hyperplasia and endometrial carcinoma were significantly higher than in the control group with normal endometrium.

[Detection of human papillomavirus genome in cervical squamous intraepithelial lesions].

Objectives: The aim of this work was the assessment of the correlation between different types of HPV and abnormal stages of uterine cervix.

Materials And Methods: The smears were simultaneously collected for both cytooncologic examination and PCR identification of HPV viruses. Cytologic smears were classified according to the Bethesda system.

[Chromosome instability in women with genital organs carcinoma].

Objectives: The aim of the current work was the assessment of the mutagen susceptibility of chromosomes of patients with carcinomas in comparison to healthy volunteers. It was interesting whether the bleomycin assay can be useful for searching for more susceptible to cancer disease individuals.

Materials And Methods: There were 4 groups of patients analysed: controls and three test groups (patients with uterine cervix carcinoma, endometrium carcinoma and ovarian carcinoma).

[The influence of demographic and behavioral factors on the risk of human papillomavirus infection].

Objectives: The aim of this work was the assessment of correlation between different types of HPV and chosen factors: the number of pregnancies, childbirths and smoking habits.

Materials And Methods: Patients were examined in the Gynaecology Clinic, Silesian Medical Academy in Zabrze from 1998 until 2000. They were either hospital patients or women subjected to routine cytological examination.

Changes in insulin-like growth factor I, 17-b-estradiol, and progesterone in postmenopausal women with benign and malignant ovarian tumours.

Background: The aim of this research was to observe changes in IGF-I and steroid hormones in postmenopausal women with benign and malignant ovarian tumors.

Material And Methods: The concentrations of insulin-like growth factor I (IGF-I), 17-b-estradiol and progesterone were examined by radioimmunological assay in three groups of postmenopausal women: patients with malignant ovarian tumors, patients with benign ovarian tumors, and healthy women. In all three groups the age and body mass index (BMI) were comparable.

[Laparotomy performed in pregnant women due to non-obstetrical causes].

Objective: The clinical characteristics of laparotomy during pregnancy were investigated.

Materials And Methods: A series of 24 cases of laparotomy during pregnancy was investigated with respect to clinicopathologic features and outcome.

Results: Among 23 cases there were 20 ovarian tumors, 2 acute appendicitis and 2 uterine fibroid.

[Carrier of numerical chromosome abnormalities in infertile married couples].

Objectives: Genetic anomalies are one of many conditions causing infertility.

Design: The aim of the study was to define the frequency of numerical chromosome aberrations in infertile married couples.

Materials And Methods: Metaphasal chromosomes were analysed by G-T-G stration in 650 patients, i.

[Computer analysis of a cardiotocogram and parameters of acid-base balance in capillary blood of the infant].

Our objective in this study was to compare the parameters of the acid-base balance in the capillary blood 60 minutes after delivery with the antenatal cardiotocographic computer analysis. Our study included 64 infants delivered vaginally on term. The basic criterion to classify into the examined group and control group was a pH result of the capillary blood equal to 7.