Stereotactic-Guided Transcerebellar Cisternoperitoneal Shunt Placement for Idiopathic Intracranial Hypertension.

Background: Idiopathic intracranial hypertension (IIH) can cause debilitating symptoms and optic nerve ischemia if untreated. Cerebrospinal fluid diversion is often necessary to reduce intracranial pressure; however, current ventriculoperitoneal and lumboperitoneal shunting techniques have high failure rates in patients with IIH.

Objective: To describe our experience treating IIH with a novel stereotactic-guided transcerebellar cisternoperitoneal shunt (SGTC-CPS) technique that places the proximal shunt catheter in the posterior cisterna magnum.

Direct targeting of the ventral intermediate nucleus of the thalamus in deep brain stimulation for essential tremor: a prospective study with comparison to a historical cohort.

Objective: The ventral intermediate nucleus of the thalamus (VIM) is an effective target for deep brain stimulation (DBS) to control symptoms related to essential tremor. The VIM is typically targeted using indirect methods, although studies have reported visualization of the VIM on proton density-weighted MRI. This study compares the outcomes between patients who underwent VIM DBS with direct and indirect targeting.

A novel approach for the treatment of Morgagni hernias: robotic transabdominal preperitoneal diaphragmatic hernia repair.

Purpose: We introduce a novel approach to the surgical repair of Morgagni hernias (MHs) utilizing the robotic transabdominal preperitoneal repair (rTAPP) approach. Borrowed from our previous and robust experience with rTAPP repairs for hernias of the anterior abdominal wall, this technique boasts the benefits of hernia sac reduction, the use of an uncoated mesh in an extraperitoneal plane, and minimal fixation leading to lower postoperative pain relative to other approaches.

Methods: To evaluate the effectiveness of this novel approach, five consecutive symptomatic Morgagni hernias (MHs) were repaired with the rTAPP approach.

Medical student wellness in the United States during the COVID-19 pandemic: a nationwide survey.

Background: As United States (US) medical students suffer higher rates of depression and anxiety than the general population, the wellness of medical students is particularly salient. One definition describes wellness as having eight dimensions: Intellectual, emotional, physical, social, occupational, financial, environmental, and spiritual. As the coronavirus (COVID-19) pandemic poses unique challenges for medical students, we aimed to compare medical student wellness before and during the COVID-19 pandemic.

Omeprazole-clopidogrel interaction and neurovascular complications after flow-diverter device placement.

Background: Omeprazole is a common proton pump inhibitor that interferes with the hepatic activation of clopidogrel and potentially reduces its platelet-inhibitory effect. Omeprazole has been shown to increase P2Y levels and adverse cardiovascular outcomes in patients treated with drug-eluting stents. However, omeprazole use among patients treated with flow-diverting stents for intracranial aneurysms has not been evaluated.

Corrigendum: Middle Meningeal Artery Embolization for Chronic Subdural Hematoma.

[This corrects the article DOI: 10.3389/fneur.2020.

Perioperative complications of deep brain stimulation among patients with advanced age: a single-institution retrospective analysis.

Objective: Deep brain stimulation (DBS) is an elective procedure that can dramatically enhance quality of life. Because DBS is not considered lifesaving, it is important that providers produce consistently good outcomes, and one factor they usually consider is patient age. While older age may be a relative contraindication for some elective surgeries, the progressive nature of movement disorders treated with DBS may suggest that older patients stand to benefit substantially from surgery.

Middle Meningeal Artery Embolization for Chronic Subdural Hematoma.

Chronic subdural hematoma (cSDH) is a common disease process associated with significant morbidity that occurs most often in elderly patients. Asymptomatic patients are typically treated conservatively, with surgical intervention reserved for patients with symptomatic and/or large hematomas that cause brain compression. However, conservatively managed cSDH cases frequently progress, and surgical evacuation of cSDH is associated with high rates of complication and recurrence.

A Large Sporadic Intra-abdominal Desmoid-Type Fibromatosis in a Young Male: A Case Report.

Desmoid type fibromatosis (DTF) is a rare benign tumor of connective tissue origin. While these tumors are typically not malignant, they can exhibit aggressive growth patterns causing mass effect on surrounding organs. These tumors typically present in the extremities and abdominal wall, rarely occurring in the mesentery, and abdominal organs.

Multicenter Real-World Assessment of the Effectiveness of V-Go Wearable Insulin Delivery Device in Adult Patients with Type 2 Diabetes (ENABLE Study): A Retrospective Analysis.

Purpose: Patch-like wearable insulin delivery devices are gaining acceptance as a treatment modality for insulin delivery in patients with diabetes. These devices aim to simplify and optimize insulin delivery while reducing barriers associated with a basal-bolus insulin regimen. As clinicians aim to learn more about this method of insulin delivery, real-world evidence can provide insight for patient identification and treatment guidance.

Cross-sectional study of readmissions to the psychiatric ward of Hospital Estadual Mário Covas in Santo André, state of São Paulo, between 2008 and 2015.

Objectives: To assess the sociodemographic and diagnostic profile of data related to psychiatric readmissions to the psychiatric ward at Hospital Estadual Mário Covas between January 2008 and September 2015, in order to investigate the possible correlation between the rate of admission and readmission and the presence or absence of a discharged patient unit or other outpatient treatment unit.

Methods: This was a cross-sectional, descriptive study. Data on patients readmitted during the study period were sourced from a statistical analysis of the Hospital Estadual Mário Covas database using STATA 11.

Progesterone level at oocyte retrieval predicts in vitro fertilization success in a short-antagonist protocol: a prospective cohort study.

Objective: To evaluate the distribution of P levels on the day of oocyte retrieval as it relates to pregnancy outcome in an antagonist protocol, which may be at higher risk for elevated P levels.

Design: Prospective cohort study.

Setting: Academic IVF center.

Luminorefrigeration: vibrational cooling of NaCs.

We demonstrate the use of optical pumping of kinetically ultracold NaCs to cool an initial vibrational distribution of electronic ground state molecules X(1)Σ(+)(v ≥ 4) into the vibrational ground state X(1)Σ(+)(v=0). Our approach is based on the use of simple, commercially available multimode diode lasers selected to optically pump population into X(1)Σ(+)(v=0). We investigate the impact of the cooling process on the rotational state distribution of the vibrational ground state, and observe that an initial distribution, J(initial)=0-2 is only moderately affected resulting in J(final)=0-4.

Photoassociation studies of ultracold NaCs from the Cs 6(2)P(3/2) asymptote.

A combination of pulsed depletion spectroscopy and photoassociation spectroscopy is utilized to assign photoassociation spectra of NaCs. These methods investigate the ab initio Ω = 2 potential energy curve and indicate a previously unknown avoided crossing between the (3)Ω = 1 and (4)Ω = 1 electronic states. We present rotational assignments of deeply bound singlet ground state molecules, an improved C(6) coefficient for the (4)Ω = 1 and assignments for all twenty-three photoassociation resonances detuned from the Cs 6(2)P(3/2) asymptote.

Is a premature rise in luteinizing hormone in the absence of increased progesterone levels detrimental to pregnancy outcome in GnRH antagonist in vitro fertilization cycles.

Objective: To determine whether a premature rise in the level of luteinizing hormone (LH) without a concomitant increase in the level of progesterone is detrimental to pregnancy outcome in flexible gonadotropin-releasing hormone (GnRH) antagonist in vitro fertilization (IVF) cycles.

Design: Retrospective cohort study.

Setting: Large academic IVF practice.

Random-start gonadotropin-releasing hormone (GnRH) antagonist-treated cycles with GnRH agonist trigger for fertility preservation.

Objective: To describe our experience with random-start IVF with the use of GnRH agonist for final oocyte maturation, to reduce the risk of ovarian hyperstimulation syndrome.

Design: Case series.

Setting: University-based center for reproductive endocrinology and infertility.

Complex X chromosome rearrangement delineated by array comparative genome hybridization in a woman with premature ovarian insufficiency.

Objective: To investigate candidate genes affected by a complex X chromosome rearrangement that may play a role in the diagnosis of spontaneous premature ovarian insufficiency (POI).

Design: Prospective cytogenetic analysis, fluorescence in situ hybridization (FISH) analysis and oligonucleotide array comparative genome hybridization (CGH).

Setting: University medical center.

The relationship between perceived stress, acupuncture, and pregnancy rates among IVF patients: a pilot study.

Unlabelled: The aim of this paper was to determine the effect of acupuncture on perceived stress levels in women on the day of embryo transfer (ET), and to determine if perceived stress levels at embryo transfer correlated with pregnancy rates. The study was an observational, prospective, cohort study based at the University IVF center.

Patient(s): 57 infertile patients undergoing IVF or IVF/ICSI.

Gonadotropin-releasing hormone agonist or human chorionic gonadotropin for final oocyte maturation in an oocyte donor program.

Objective: To compare leuprolide acetate to hCG as the trigger for final oocyte maturation in oocyte donor cycles.

Design: Retrospective review.

Setting: Academic IVF donor program.

GnRH agonist long protocol vs. a single 3-mg gnRH antagonist: a comparison of 2 protocols for pituitary down-regulation in oocyte donor-controlled ovarian hyperstimulation cycles.

Objective: To compare ovarian stimulation outcomes for 2 protocols of pituitary down-regulation in a group of fertile women.

Study Design: Retrospective outcome analysis of 35 healthy oocyte donors participating in a university-affiliated in vitro fertilization donor program from 1999 to 2004. Consecutive donor cycles were grouped according to the agent used for down-regulation (n = 27 GnRH agonist, n = 31 GnRH antagonist).

Fetal bony pelvis in the bladder exstrophy complex: normal potential for growth?

Objectives: To provide the first look at the bony histologic features of fetuses with the exstrophy complex, specifically evaluating the endochondral ossification, stage of development, and microscopic potential for normal growth.

Methods: Three fetuses between 28 and 30 weeks of gestation, one with classic bladder exstrophy, one with cloacal exstrophy, and one control, were obtained from France. The bony pelves were dissected and preserved in formalin, and multiple representative sections were sliced from all pelvic areas: pubis, ischium, ilium, and sacrum.

Connections of the bladder plate and bladder neck with the bony pelvis in a fetus with classic bladder exstrophy.

Objectives: To demonstrate that the bladder plate and bladder neck in classic bladder exstrophy are laying on smooth muscle fibers that extend laterally to the pubic bones.

Methods: We compared a male fetus of 28 weeks' gestational age with classic bladder exstrophy with a normal fetus of the same age. The specimens were divided into two parts by a midsagittal section, from the bladder neck to the membranous urethra.

Evaluation of the bony pelvis in classic bladder exstrophy by using 3D-CT: further insights.

Objectives: To provide a complete look at the bony pelvis in children with classic bladder exstrophy: dimensions, orientation, and relationships.

Methods: Three-dimensional computed tomography was used in 6 boys and 1 girl, 5 of whom underwent primary closure and 2 who underwent reclosure at 4 and 8 months. These exstrophy pelves (intrapelvic angles and osseous dimensions) were compared with 26 age and sex-matched controls.

The AP diameter of the pelvis: a new criterion for continence in the exstrophy complex?

Objective: Reconstructive surgery of bladder exstrophy remains a challenge. By using CT of the pelvis, we suggest a new pre- and post-operative investigative procedure to define the AP diameter (APD) as a predictive criterion for continence in this anomaly.

Patients And Methods: Three axial CT slices were selected in nine children with exstrophy who had undergone neonatal reconstructive surgery.