Does Estimated Glomerular Filtration Rate Predict In-Hospital Mortality in Acutely Unwell Hospitalized Oldest Old?

Globally the population of older adults is the fastest growing age group. Estimated glomerular filtration rate (eGFR) is an estimation of true kidney function with lower eGFR associated with higher mortality. However, few studies explore eGFR's prognostic value in the nonagenarian.

Studies on amidated pectins as potential carriers in colonic drug delivery.

Amidated pectins have been assessed, in-vitro, for their potential value in colonic drug delivery. The monitoring of the release of a model soluble drug, paracetamol, gives a sensitive indication of the behaviour of the pectins under simulated gastrointestinal conditions. Inclusion of calcium as a cross-linking agent increased the viscosities of amidated pectin gels to a maximum value.

Pectin/ethylcellulose film coating formulations for colonic drug delivery.

Purpose: The purpose of the study was to investigate the potential of pectin, ethylcellulose combinations as a practical film coating for colonic delivery.

Methods: Combinations of pectin and ethylcellulose, in the form of an aqueous dispersion, were used as coating formulations. Paracetamol cores were used as the substrate.