Publications by authors named "Wakana Ikezawa"
Astrocyte Ca signaling is facilitated in Scn1a mouse model of Dravet syndrome.
Biochem Biophys Res Commun
February 2023
Article Synopsis
- Dravet syndrome (DS) is a severe form of epilepsy that starts in infancy and is often linked to mutations in the SCN1A gene, which is crucial for sodium channels in brain neurons.
- This study investigates the role of astrocytes, a type of brain cell, in DS by examining calcium signaling in genetically modified mice with SCN1A mutations.
- The findings reveal that these astrocytes exhibit altered calcium signaling dynamics, suggesting that changes in astrocyte function may contribute to the development of Dravet syndrome.