[Selected markers of oxidative stress and carcinogenic trace elements concentrations in the renal cell carcinoma tissue].

Unlabelled: In industrialized countries, increasing concentrations of harmful trace elements in the human environment increases their concentration in the organs, which in turn may be responsible for the growth of cancer including cancer of the kidney. Trace elements by increasing the concentration of active free radicals damage cell DNA, and in a consequence increase the risk of carcinogenesis. The aim of this study was to determine concentrations of biochemical markers providing an increase in the concentration of free radicals in the cell kidney cancer and renal cortical tissue, from which it originates and to attempt correlation of these markers with the concentration of carcinogenic trace elements identified in these same tissues using spectral analysis of PIXE (Proton induced X-Ray Emmision).

Myocardial damage in thyrotoxicosis--ultrastructural studies.

Lack of uniform views concerning subcellular image and possible meaning of free radicals in the myocardial damage prompted us to study rat hearts submitted for chronic thyrotoxicosis. The studies were performed on 30 Wistar white rats. The material was obtained from anterior wall of the left ventricle of the heart.

[Activity of some indicator enzymes in myocardium of rats after adrenalectomy, stimulation and inhibition of adrenal function].

An activity of some selected indicator enzymes in rats after adrenalectomy, stimulation and inhibition of adrenal glands has been investigated in the heart muscle. An increase in the activity of CPK, isoenzyme CK-MB, LDH and AspAT after the adrenal stimulation (Synacthen) have been observed. As well as significant decrease in the activity of these enzymes after adrenalectomy and inhibition (by use Orimeten-aminoglutethimide) functioning of adrenal glands have been observed.

[Influence of chronic poisoning with cadmium on some lipid compounds in heart muscle and aorta of rabbits].

The detection of the influence of chronic poisoning with cadmium on some lipid metabolism in heart muscle and aorta of rabbits was the main object of the paper. A distinct cumulation of cadmium in the heart muscle was observed. However, its excessive accumulation in the wall of the aorta was not noted.

[Reaction of dental methacrylate material in in vivo tests--selected hematologic and immunologic indices].

Wistar rats were implanted subcutaneously with 2.5 x 6 mm cylindrical matrices, made from the home-made metacrylate material Akpol S, and, for comparative purposes, with the imported materials Trevalon and Superacryl. At different time intervals quantitative and qualitative analyses of the picture of leucocytes and of blood plasma proteins were carried out in groups of animals implanted with the above-mentioned materials and in a control one.

[Histopathologic evaluation of the reactivity of soft tissue to dental acrylate implants--in vivo examinations].

Wistar rats were implanted subcutaneously with samples of the home-made metacrylate material Akpol S and, for comparative purposes, with samples of the imported materials Trevalon and Superacryl. Throughout a period of 7 weeks, at 7-day intervals, sections of the tissues surrounding implants were collected from the animals and examined histopathologically. No differences in the character of the inflammatory reaction ensuing around the implants made from the three tested materials were observed.

In vitro study of (2S, 2'S) N,N'-dimethyl-N, N'-bis [1(3', 4', 5'-trimethoxybenzoyloxy) butyl-2] ethylenediamine salts and their bioavailability.

The aim of this study was to improve the oral dosage form of the title compound. The study include base, dihydrochloride and dimaleate. In vitro study was carried out on rat intestine, in vivo on rats and rabbits.

The chronic toxicity of the preparation M-71 (Craviten).

The studies of chronic toxicity of the preparation M-71 (Craviten) were carried out on rats and mice. The body weight, absolute and relative weight or organs, haematocrit, the number of erythrocytes and leukocytes, the proportional content of leukocytes, OB value, activity of aminotransferases (AspAT and AlAT), the level of glucose in the blood serum and the histopathology of some organs were investigated. Moreover, in rats receiving M-71 intraperitoneally, the amount of electrolytes and the daily excretion of urine was studied.