Clinical and genetic analysis of three families with familiar amyloid polyneuropathy.

Objective: To study the clinical and genetic features of familiar amyloid polyneuropathy (FAP).

Methods: Three families of suspected FAP in China mainland and Macau were investigated on aspects of clinical manifestations, histological features, and gene analysis.

Results: All the 3 families had the clinical features of sensory and motor polyneuropathies, and notable vegetative nerve involvements.