Publications by authors named "Wai-Yu Li"
Article Synopsis
- * Research on Dlgap2 mutant mice showed that while their overall odor detection was similar to normal mice, they showed less interest in certain smells (banana and almond) but reacted more to unfamiliar bedding smells.
- * The absence of DLGAP2 protein in Homo mutant mice affected their brain's response to odors, which suggests altered synaptic signaling in their olfactory systems and could inform future strategies for diagnosing and treating ASD-related olfactory issues.
Schizophrenia is a multifactorial developmental neuropsychiatric disorder. This study examined the interplay of maternal infection and postweaning social isolation, which are prenatal and postnatal risk factors, respectively. Pregnant mice received poly I:C or saline injection on gestation day 9 and the pups were weaned at postnatal day 28.
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- Disrupted-in-Schizophrenia 1 (DISC1) is linked to various psychiatric disorders, and researchers created a mutant mouse model with a specific genetic deletion to study its effects on schizophrenia.
- * Heterozygous Disc1 mutant mice showed increased locomotor activity after amphetamine treatment compared to wild-type mice, indicating altered dopaminergic regulation in their brains.
- * Structural changes were observed in the striatum of mutant mice, including reduced complexity in neurons and decreased dendritic spine density, suggesting a potential connection between DISC1 gene variation and schizophrenia symptoms.
Environmental factors such as prenatal infection are involved in the pathogenic processes of neurodevelopmental psychiatric disorders. In the present study, we administered a viral mimic, polyriboinosinic-polyribocytidylic acid (poly I:C, 20 mg/kg, i.p.
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