Cigarette smoking hinders human periodontal ligament-derived stem cell proliferation, migration and differentiation potentials.

Cigarette smoking contributes to the development of destructive periodontal diseases and delays its healing process. Our previous study demonstrated that nicotine, a major constituent in the cigarette smoke, inhibits the regenerative potentials of human periodontal ligament-derived stem cells (PDLSC) through microRNA (miRNA) regulation. In this study, we hypothesized that the delayed healing in cigarette smokers is caused by the afflicted regenerative potential of smoker PDLSC.

Directing adult human periodontal ligament-derived stem cells to retinal fate.

Purpose: To investigate the retinal fate competence of human postnatal periodontal ligament (PDL)-derived stem cells (PDLSC) through a directed differentiation mimicking mammalian retinogenesis.

Methods: Human teeth were collected from healthy subjects younger than 35 years old. Primary PDLSC were isolated by collagenase digestion and cultivated.

Mucoepidermoid carcinoma expleomorphic adenoma of the submandibular gland.

We described a rare case of carcinoma expleomorphic adenoma in which mucoepidermoid carcinoma arise from a previous incompletely excised pleomorphic adenoma of the submandibular gland. The tumor was surgically resected along with a modified radical neck dissection and postoperative radiotherapy. The patient remained disease free 3 years after the last operation.

Recurrent ameloblastoma presenting in the temporal fossa.

Recurrent ameloblastoma presenting in the temporal fossa is a rarely reported clinical entity. This report presents a case of temporal recurrence that occurred 30 years after the initial surgical treatment. A 45-year-old woman had a history of multiple enucleations for recurrences of her right mandibular ameloblastoma.