Publications by authors named "Wai-Man Lam"

Article Synopsis
  • - The study investigates how self-efficacy (SE) among caregivers influences the relationship between their unmet support needs and their health-related quality of life (HRQOL) while caring for palliative cancer patients.
  • - Researchers analyzed data from 125 family caregivers and found that unmet support needs negatively impacted mental HRQOL, with caregiving SE specifically in "care for the care recipient" acting as a mediator.
  • - The results suggest that improving caregiving SE could be key in helping caregivers better cope with their unmet needs, ultimately enhancing their HRQOL, highlighting the importance of supportive interventions from healthcare providers.
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Article Synopsis
  • - The study evaluated the reliability, validity, and acceptability of the Chinese version of the Carer Support Needs Assessment Tool (CSNAT) for family caregivers in palliative care in Hong Kong, involving 125 caregivers and 10 healthcare providers.
  • - Results showed an impressive content validity index of 0.98, with significant correlations between CSNAT items and measures like caregiver burden and self-efficacy; however, it did not correlate well with social support.
  • - Most healthcare professionals found the tool useful, with high acceptability among caregivers, as 89.6% understood it well and 92.9% felt comfortable responding to its questions.
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Objectives: The rapid ageing population of Hong Kong has a high demand on oncology and palliative care (PC) service. This study was the first territory-wide assessment in Hong Kong to assess the palliative service coverage in patients with advanced cancer in the past decade.

Methods: Cancer deaths of all 43 public hospitals of Hong Kong were screened.

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Integrated palliative care in oncology service has been widely implemented in Hong Kong since 2006. The study aimed to review its impact on end-of-life outcomes and overall survival (OS) of cancer patients, as well as its utilization of health care resources in the past 10 years. Cancer deaths of all 43 public hospitals of Hong Kong were screened.

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Palliative care patients experience a variety of needs and perceive their quality of life as being only fair. This study adopted a single-group repeated-measure design to investigate the effect of horticultural therapy on the quality of life of palliative care patients using the Quality of Life Concern in End of Life Questionnaire. Significant differences in the domains of "existential distress" and "health care concern" were observed immediately postintervention and at 4 weeks postintervention, respectively.

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This paper examines the reasons for the relatively low democratic support (DS) in Hong Kong in the context of competing values and choices based on the previous Asian Barometer Surveys. In so doing, it establishes a three-factor theoretical model that includes survey attitudinal statements related to authoritarianism (AU), nationalism (NA) and economic evaluations (EC) on DS. Using confirmatory factor analysis (CFA), the analysis shows that the hypothesized model is a very good fit.

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Aim: This article reports a study to examine the meaning of hope from the perspective of Chinese advanced cancer patients in Hong Kong.

Methods: Semi-structured interviews were conducted with a convenience sample of advanced cancer patients recruited from the palliative care unit of a local hospital. Data were saturated after 17 participants were interviewed.

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This retrospective study aimed to compare noncancer deaths with cancer deaths in the following: 1) utilization of the public health care system in the last six months of life; 2) end-of-life care received; and 3) documentation of the advance care planning (ACP) process. The following sample was recruited from the deaths in 2006 in four public hospitals for analysis: 656 noncancer deaths consisting of 239 deaths from chronic renal failure (CRF), 242 deaths from chronic obstructive pulmonary disease (COPD) and 175 deaths from congestive heart failure (CHF), and 183 cancer deaths. Only 1.

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Hope is considered a coping strategy as well as a factor that enhances quality of life for patients with advanced cancer. Most studies on the meaning of hope are from the patients' perspective. However, the health-care professionals' view is also important since it may affect their practice.

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Aim: This paper is a report of an exploration of the phenomenon of existential distress in patients with advanced cancer from the perspectives of healthcare professionals.

Background: Existential distress is an important concern in patients with advanced cancer; it affects their well-being and needs to be addressed in the provision of holistic care.

Method: Focus groups were conducted from November 2008 to February 2009 with physicians, nurses, social workers, occupational therapists, physiotherapists, and chaplains working in a palliative care unit that served patients with advanced cancer in Hong Kong.

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Article Synopsis
  • Hepatocellular carcinoma (HCC) often lacks the enzyme argininosuccinate synthetase (ASS), making it auxotrophic for arginine, and while arginine-depleting enzyme arginine deiminase (ADI) helps ASS-deficient tumors, many ASS-positive HCC cells remain resistant to it despite needing arginine for growth.
  • Direct evidence shows that recombinant human arginase (rhArg) effectively inhibits ASS-positive HCC cells, whereas ADI has little impact; the lack of ornithine transcarbamylase (OTC) in these cells correlates with their sensitivity to rhArg treatment.
  • Pretesting for ASS and OTC expression in tumors could predict responsiveness to arginine-depleting therapies
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