Publications by authors named "Wai Cheng Wong"
Wound healing is facilitated by biomaterials-based grafts and substantially impacted by orchestrated inflammatory responses that are essential to the normal repair process. Tropoelastin (TE) based materials are known to shorten the period for wound repair but the mechanism of anti-inflammatory performance is not known. To explore this, we compared the performance of the gold standard Integra Dermal Regeneration Template (Integra), polyglycerol sebacate (PGS), and TE blended with PGS, in a murine full-thickness cutaneous wound healing study.
View Article and Find Full Text PDFArticle Synopsis
- Native cell-membrane-derived supported lipid bilayers (SLBs) allow for the study of membrane proteins' dynamics and functions while minimizing substrate interaction through polymer cushions.
- A study examined how varying lengths of PEG polymer impacted the mobility of different membrane proteins fused with GFP, revealing that longer polymers generally increased protein mobility.
- Results indicated that all proteins reached similar diffusion coefficients at the longest polymer length, suggesting effective suspension of the SLBs above the substrate, though transient confinements were also noted for the proteins.
Single-molecule tracking is a powerful method to study molecular dynamics in living systems including biological membranes. High-resolution single-molecule tracking requires a bright and stable signal, which has typically been facilitated by nanoparticles due to their superb optical properties. However, there are concerns about using a nanoparticle to label a single molecule because of its relatively large size and the possibility of cross-linking multiple target molecules, both of which could affect the original molecular dynamics.
View Article and Find Full Text PDF