Effects of the highly COX-2-selective analgesic NSAID etoricoxib on the rate of orthodontic tooth movement and cranial growth.

Background: NSAID analgesics have found widespread use in the treatment of pain, inflammation and fever. The highly COX-2-selective NSAID etoricoxib has shown a favorable side effect profile and excellent analgesic efficacy, particularly for dental and orthodontic pain, surpassing the current standard analgesic in orthodontics, acetaminophen. However, potential side effects on the rate of orthodontic tooth movement (OTM) and cranial growth, relevant for clinical usability during orthodontic treatment, have not yet been investigated.

Impact of radiotherapy on implant-based prosthetic rehabilitation in patients with head and neck cancer: A prospective observational study on implant survival and quality of life-Preliminary results.

Purpose: To study implant-based prosthetic rehabilitation of head and neck cancer patients with focus on implant survival and quality of life.

Materials And Methods: The prospective observational study presents preliminary results of 29 edentulous head neck cancer patients (20 patients after radiotherapy) with 165 OsseoSpeed implants. Implant success after 1-year follow-up was evaluated by means of the Albrektsson criteria.

Can dental panoramic radiographic findings serve as indicators for the development of medication-related osteonecrosis of the jaw?

Objectives: The purpose of this case-control study was to find a correlation between certain imaging findings in dental panoramic radiographs and the risk for developing a medication-related osteonecrosis of the jaw (MRONJ) in patients taking antiresorptive therapy (AT).

Methods: Randomized and blinded dental panoramic radiographs of 60 patients undergoing antiresorptive drug treatment (36 patients with MRONJ, 24 patients without MRONJ) and of 60 patients without AT were analyzed by 3 experts for the following signs: sequestrum, osteosclerosis, difference in sclerosing of alveolar process and body of mandible, visible alveolar socket, enhancement and loss of lamina dura, enhancement of the oblique ridge, enhancement of the mandibular canal, proliferative periostitis and osteolytic processes at the cortex.

Results: Signs were seen significantly more often in patients undergoing AT than in the control group (CG) (osteosclerosis p-value = 0.

Strontium ranelate improved tooth anchorage and reduced root resorption in orthodontic treatment of rats.

The anchorage mechanisms currently used in orthodontic treatment have various disadvantages. The objective of this study was to determine the applicability of the osteoporosis medication strontium ranelate in pharmacologically induced orthodontic tooth anchorage. In 48 male Wistar rats, a constant orthodontic force of 0.

Differentiated analysis of orthodontic tooth movement in rats with an improved rat model and three-dimensional imaging.

Rat models currently available for analysis of orthodontic tooth movement often lack differentiated, reliable and precise measurement systems allowing researchers to separately investigate the individual contribution of tooth tipping, body translation and root torque to overall displacement. Many previously proposed models have serious limitations such as the rather inaccurate analysis of the effects of orthodontic forces on rat incisors. We therefore developed a differentiated measurement system that was used within a rat model with the aim of overcoming the limitations of previous studies.

Implant-supported fixed dental prostheses in an edentulous patient with dystrophic epidermolysis bullosa.

Purpose: This clinical report describes the use of implant-supported fixed dental prostheses (ISFDPs) in a severe case of dystrophic epidermolysis bullosa.

Materials And Methods: The patient's appearance was characterized by reduced corporal growth and severe mutilation of the hands and feet. He was first examined at age 20.

Primary stability of a conical implant and a hybrid, cylindric screw-type implant in vitro.

Purpose: The differences with respect to primary stability between 2 Camlog implants, a conical implant, and a hybrid cylindric screw-type implant, were investigated in vitro. The effect of underdimensioned implant bed preparation was also studied for both implant designs.

Materials And Methods: In an in vitro model the stability of different implants in fresh porcine iliac bone blocks was measured using torque moment values, the Periotest, resonance frequency analysis, and push-out testing.

Reconstruction of mandibular defects following tumor ablation by vertical distraction osteogenesis using intraosseous distraction devices.

Objectives: Distraction osteogenesis has recently evolved a challenging technique to overcome major drawbacks of conventional augmentation procedures. We, therefore, report the application of miniaturized intraosseous distraction devices for the rehabilitation of mandibular defects due to ablative tumor surgery.

Methods: In 10 patients who had undergone box-shaped or segmental resections, augmentation of the residual mandibular bone or of full thickness iliac crest grafts was performed by intraosseous implant-shaped distractors.

The use of implant-supported prostheses in the functional and psychosocial rehabilitation of tumor patients.

Purpose: The present study investigated the residual functional constraints as well as the psychosocial rehabilitation of tumor patients following prosthetic treatment with implant-supported dentures.

Materials And Methods: A clinical examination and semistructured interview were performed in 66 of 132 consecutive patients who underwent tumor resection and subsequent implant-supported restoration between 1985 and 1997.

Results: Functional and psychosocial constraints were improved by between 91% (general comfort) and 47% (social reintegration) of all cases, but these constraints were never fully compensated for.

[Adenomatoid odontogenic tumor in calcifying odontogenic cyst].

Background: Adenomatoid odontogenic tumors (AOT) and calcifying odontogenic cysts (COC, Gorlin's cyst) are rare benign specificities of odontogenic tumors. Most odontogenic tumors are lesions of embryonic odontogenic tissue. Radiographically, odontogenic tumors may mimic an odontogenic follicular cyst.

Surgically assisted rapid palatal expansion. An acoustic rhinometric, morphometric and sonographic investigation.

This study aimed to evaluate the effect of surgically assisted rapid palatal expansion on the skeletal structures of the midface. Ten patients (mean age 28.5 years) were investigated by means of acoustic rhinometry, study model analysis and sonography before and after the procedure of surgically assisted rapid palatal expansion.

[Therapy monitoring with 2-(18F)-FDG positron emission tomography after neoadjuvant radiation treatment of mouth carcinoma].

Background: Combined protocols of radiation therapy and surgical resection, as applied in advanced oral cancer, rely on objective and early assessment of treatment response to radiation therapy. Non-responders require immediate radical salvage surgery even in spite of substantial operative risks, while complete or subtotal response may give reasons for continuing the conservative approach. Therefore, we investigated radiation response by FDG-PET for early monitoring of oral cancer.

Acoustic airway profiles in unilateral cleft palate patients.

Objective: This study investigates the nasal airway in unilateral cleft palate patients by means of a noninvasive, objective diagnostic method that provides topographic information about the airway profile.

Design: A consecutive sample of patients was measured.

Setting: Cleft palate rehabilitation center of the University of Mainz, Germany.

[Tissue damage and regeneration after laser surgery using different scanning systems].

Introduction: Laser systems are frequently used in dentistry. New laser scanner technologies are promising more homogeneous ablation of pathological ablations of the skin and mucosa. The theoretical advantages of these systems have not yet been sufficiently evaluated by histological findings.

Clinical and microbiological efficacy of single dose cefuroxime prophylaxis for dental surgical procedures.

In a prospective controlled randomised trial of 59 patients the effect of a single dose of cefuroxime before multiple tooth extractions on the clinical findings and occurrence of bacteraemia was studied. In one group 1.5 g cefuroxime was administered intravenously 10 min before start of surgery.

[Prognosis and prognostic factors of endosseous implants in the irradiated jaw].

In comparison to tumor patients not receiving radiotherapy, the rehabilitation of masticatory function after head and neck irradiation is limited due to radiation-induced caries, radioxerostomia, and the risk of osteoradionecrosis. This study focused on implants in the irradiated jaw and on the evaluation of the prognosis and the effect of potential factors on the prognosis. The retrospective study covered 197 implants (47 patients) from 1988 to 1997.

[Value of (F18)-2-fluorodeoxyglucose PET scanning in staging mouth cavity carcinoma. Comparative evaluation of PET findings before and after preoperative radiochemotherapy with histological and computerized tomography findings].

Objective: The lack of sensitivity and specificity of conventional imaging techniques based on morphological critera is responsible for considerable limitations in the staging and surveillance of oral cancer. Therefore, this study investigates the contribution of [F18]-2-fluordesoxyglucose (FDG) positron emission tomography (PET) to tumor management with special regard to lymphnode involvement and therapeutic monitoring after radiotherapy.

Design: Prospective observational study.

Objective evaluation of velopharyngeal function by acoustic reflection measurements.

Objective: To investigate whether acoustic pharyngometry is capable of discriminating velopharyngeal mobility in cleft and non-cleft subjects by determination of epipharyngeal volume changes with active muscle function.

Design: Case control study, consecutive sample.

Setting: Cleft palate rehabilitation centre.

Objective evaluation of velopharyngeal function by acoustic reflection measurements.

Objective: To investigate whether acoustic pharyngometry is capable of discriminating velopharyngeal mobility in cleft and non-cleft subjects by determination of epipharyngeal volume changes with active muscle function.

Design: Case control study, consecutive sample.

Setting: Cleft palate rehabilitation centre.

Preoperative assessment of airway patency in the planning of corrective cleft nose surgery.

Objective: To investigate acoustic assessment of complex structural anomalies in cleft lip and palate associated nasal deformities and its impact on the planning of corrective rhinosurgery.

Patients: Twenty-three consecutive patients with unilateral CL(P) during routine consultations, three of them prior to corrective surgery.

Intervention: Acoustic measurements of the nasal airway cross-sectional area were obtained for both nasal cavities.

Objective, noninvasive evaluation of velopharyngeal function in cleft and noncleft patients.

Objective: The purpose of this study was to investigate a new diagnostic method that provides an approach to noninvasive, objective measurement of velopharyngeal movement by acoustic determination of epipharyngeal volume changes with velopharyngeal muscle function.

Design: This was a case control study, using consecutive samples.

Setting: This study took place at the Cleft Palate Rehabilitation Center of the University of Mainz, Germany.