Temporal Dementia and Cognitive Impairment Trends in the Very Old in the 21st Century.

Background: Long-increasing dementia incidence and prevalence trends may be shifting. Whether such shifts have reached the very old is unknown.

Objective: To investigate temporal trends in the incidence of dementia and cognitive impairment and prevalence of dementia, cognitive impairment, Alzheimer's disease, vascular dementia, and unclassified dementia among 85-, 90-, and ≥ 95-year-olds in Sweden during 2000-2017.

DNA binding and telomere length regulation of yeast RAP1 homologues.

The repressor activator protein 1 (RAP1) has many important functions in Saccharomyces cerevisiae. At the chromosome ends, it is a negative regulator of telomere length. Here, we show that Saccharomyces castellii/Saccharomyces dairensis telomeric sequences inserted into a S.

Neurokinin 1 receptor and relative abundance of the short and long isoforms in the human brain.

Substance P exerts its various biochemical effects mainly via interactions through neurokinin-1 receptors (NK1). Recently, the NK1 receptor has attracted considerable interest for its possible role in a variety of psychiatric disorders including depression and anxiety. However, little is known regarding the anatomical distribution of NK1 in the human central nervous system (CNS).

Analysis of the RAP1 protein binding to homogeneous telomeric repeats in Saccharomyces castellii.

The repressor activator protein 1 (RAP1) plays a role in telomere structure and function inS. cerevisiae. Here, the RAP1 homologue was identified and cloned from the budding yeast Saccharomyces castellii (scasRAP1).

Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study.

The diverse biological actions of extracellular nucleotides in tissues and cells are mediated by two distinct classes of P2 receptor, P2X and P2Y. The G protein-coupled P2Y receptors comprise at least six mammalian subtypes (P2Y(1,2,4,6,11,12)), all of which have been cloned from human tissues, as well as other species. The P2Y receptor subtypes differ in their pharmacological selectivity for various adenosine and uridine nucleotides, which overlap in some cases.

Saccharomyces cerevisiae RAP1 binds to telomeric sequences with spatial flexibility.

A wide divergence has been detected in the telomeric sequences among budding yeast species. Despite their length and homogeneity differences, all these yeast telomeric sequences show a conserved core which closely matches the consensus RAP1-binding sequence. We demonstrate that the RAP1 protein binds this sequence core, without involving the diverged sequences outside the core.

NUTRITIONAL CYTOPENIA IN MONKEYS RECEIVING THE GOLDBERGER DIET.

Experiments are reported upon young rhesus monkeys which were given a diet essentially the same as the Goldberger black tongue-producing diet, supplemented in various ways. Those receiving the unsupplemented diet developed the syndrome characterized by leucopenia, anemia, gingivitis, diarrhea, and death, which has been previously described in monkeys receiving our diet of refined foodstuffs. An animal receiving the Goldberger diet supplemented with ascorbic acid and liver extract exhibited normal growth and development and has maintained a normal blood picture for approximately 2 years.