Novel sulpiride-loaded solid lipid nanoparticles with enhanced intestinal permeability.

Background: Solid lipid nanoparticles (SLN), novel drug delivery carriers, can be utilized in enhancing both intestinal permeability and dissolution of poorly absorbed drugs. The aim of this work was to enhance the intestinal permeability of sulpiride by loading into SLN.

Methods: A unique ultrasonic melt-emulsification method with minimum stress conditions was used for the preparation of SLN.