Purpose: There are limited treatment options for advanced melanoma that have progressed during or after immune checkpoint inhibitor therapy. Intratumoral (IT) immunotherapy may improve tumor-specific immune activation by promoting local tumor antigen presentation while avoiding systemic toxicities. The phase 3 ILLUMINATE-301 study (ClinicalTrials.
View Article and Find Full Text PDFBackground: There is an ongoing debate about the most appropriate method for reconstructing the pancreas after a pancreaticoduodenectomy (PD). This study assessed the impact of pancreaticogastrostomy (PG) with an external pancreatic stent on postoperative outcomes following PD in high-risk patients.
Patients And Methods: This study involves a propensity score-matched analysis of high-risk patients who underwent PD with PG reconstruction.
This paper investigates the procedure for determining the new Hijri Month between Brunei, Indonesia, Malaysia, and Singapore. It endeavours to understand the reason for dissimilarity in terms of practice between these four nations in commencing Hijri Month of and despite sharing the same lunar crescent visibility criterion. This study is conducted through the examination of literature with regards to regulations of the lunar crescent visibility criterion between these countries.
View Article and Find Full Text PDFContext: A significant class of solid-state materials, Ruddlesden-Popper (RP) perovskites are well-known for their rich chemical compositions that make them excellent electrocatalysts. Therefore, in this work, we conduct thorough analysis of RP perovskites, specifically CaXO (X = Zr, Hf). We delve into the structural, electronic, optical, and mechanical properties presenting their insights for the first time.
View Article and Find Full Text PDFPolyethylene terephthalate (PET) pollution is an emerging environmental hazard because of its recalcitrance to degradation. This study proposes an mutagenesis of LipKV1 from for improved lipase-PET interaction, using the PET-degrading cutinase (TfCut2) as the structural benchmark. Results revealed that lid deletion on LipKV1 (LipKV1_LE) facilitated the entry of PET into the active site.
View Article and Find Full Text PDFOpportunities exist to provide high-quality breast imaging fellowship training in the community setting. Various challenges exist, however, including obtaining funding for a fellowship position, creating an educational curriculum in a potentially nonacademic environment, and developing an overall competitive program that will attract radiology trainees. Here, we explore factors that contribute to the establishment of an academic breast imaging fellowship program in the community setting based on experience, including (1) providing guidance on how to secure funding for a breast imaging fellowship position; (2) developing a training curriculum based on established guidelines from the Accreditation Council for Graduate Medical Education, American College of Radiology, and Society of Breast Imaging; and (3) navigating the landscape of the recruitment process, from program branding to matching applicants.
View Article and Find Full Text PDFWhile breast cancer screening reduces mortality, disparities in access continue to limit equitable care. Medically underserved groups-including American Indian or Alaska Native, Black, Hispanic, disabled, and LGBTQ+ individuals-face significant barriers in accessing screening mammography services. This AJR Expert Panel Narrative Review leverages the National Institute on Minority Health and Health Disparities Research Framework to analyze persistent inequities in screening, focusing on race, ethnicity, socioeconomic status, disabilities, health insurance, and geography.
View Article and Find Full Text PDFVariants of concern (VOCs) of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) exhibit high infectivity due to mutations, particularly in the spike protein, that facilitate enhanced binding of virus to human angiotensin-converting enzyme 2 (hACE2). The D614G mutation, situated in S1-domain, promotes the open conformation of spike protein, augmenting its interaction with hACE2. Activated water neutralizes pathogens by damaging biological molecules; however, its effect on mutated SARS-CoV-2 or VOCs requires further exploration.
View Article and Find Full Text PDFThe phenomenon of twilight has been stipulated as naturally dependent on the variables of solar depression, aerosol concentration and ozone composition. The unique color spectrum of twilight is attributed by ozone layer and aerosol, whereas its brightness is heavily relying on the altitude of sun below horizon. While all the natural dependence is being researched extensively, the impact of light pollution on the brightness of the twilight is not being explored thoroughly.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
February 2025
Respir Med Case Rep
September 2024
Introduction: Rhodococcus is an extremely rare, gram positive, aerobic, coccobacillary organism, usually found in the soil or in dairy and livestock animals. It is most commonly affecting the immunocompromised. Only 15 % of cases have been reported in immunocompetent hosts.
View Article and Find Full Text PDFHemolytic disease of the fetus and newborn (HDFN) due to an antibody in the Kell blood group system can be associated with severe fetal anemia. This case report details the challenges of managing a Kell mother with anti-Ku that affected her fetus/newborn. A gravida 4 para 3 woman at term underwent an emergency lower caesarean section because of fetal distress.
View Article and Find Full Text PDFThe transgender population, a historically marginalized group, is growing in size, visibility, and cultural acceptance. However, lack of provider knowledge contributes to the disparities and discrimination that this group continues to face in the healthcare setting. Special considerations for transgender individuals undergoing imaging for breast/chest care can improve health equity, including appropriate evidence-based screening, tailored protocols, and inclusive radiology facilities.
View Article and Find Full Text PDFThis study explores an eco-friendly delignification technique for raw oil palm leaves (OPL), highlighting the optimized conditions of choline chloride-lactic acid deep eutectic solvent (DES)-mediated ball milling pretreatment to maximize the co-production yields of highly crystalline cellulose and lignin. Our five-level-four-factor Taguchi design identified the optimal reaction settings for cellulose production (85.83 % yield, 47.
View Article and Find Full Text PDFThe study aims to improve the viability and stability of resveratrol by encapsulating metal-based biocompatible nanocarrier for mitochondrial-targeted delivery and breast cancer treatment. For this purpose, sodium alginate coated silver nanoparticles were synthesized by in-situ reduction of silver nitrate using sodium borohydride. The prepared nanoparticles and resveratrol-loaded nanoparticles were characterized by utilizing the following instruments including X-ray diffraction (XRD), UV visible spectroscopy, Photoluminescence (PL) spectroscopy, Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Energy Dispersive X-ray (EDX), Fourier Transform Infrared (FTIR), Raman spectroscopy, Zeta potential.
View Article and Find Full Text PDF, commonly known as Indian barberry, has been traditionally used for its medicinal properties. Despite its recognized pharmacological benefits, its potential application in the food industry remains underexplored. This study aims to investigate the proximate analysis and techno-functional properties of root powder to evaluate its feasibility as a functional food ingredient.
View Article and Find Full Text PDFEnzymatic treatment on lignocellulosic biomass has become a trend in preparing nanocellulose (NC), but the process must be optimized to guarantee high production yield and crystallinity. This study offers insights into an innovative protocol using cultivated fungal cellulase and xylanase to improve NC production from raw oil palm leaves (OPL) using five-factor-four-level Taguchi orthogonal design for optimizing parameters, namely substrate and enzyme loading, surfactant concentration, incubation temperature and time. Statistical results revealed the best condition for producing NC (66.
View Article and Find Full Text PDFInt J Surg Case Rep
September 2024
Introduction & Importance: Pulmonary Artery Aneurysm is defined as the localized dilation of the pulmonary artery >1.5 times the upper normal limit or pulmonary artery measuring 4 cm. Pulmonary artery aneurysm is considered as a rare disorder having an incidence of 1 in 14,000 post-mortem examinations.
View Article and Find Full Text PDFContext: Novel optoelectronic and thermoelectric properties with broad compositional range, non-toxic nature and structural stability make halide-based double perovskites fascinating for flexible optoelectronic devices. In this work, the structural electronic, optical and transport properties of RbTlSbX (X = Cl, Br, I) were studied using density functional theory for optoelectronic devices. The elastic analysis demonstrates ductile nature, mechanical stability, anisotropic behaviour and feasibility for flexible optoelectronic devices.
View Article and Find Full Text PDFEarly nutritional management approach greatly impacts broilers' performance and resistance against coccidiosis. The current study explored the impact of post-hatch feeding with a combination of glutamine (Glut) and different levels of omega-3 on broiler chickens' growth performance, muscle building, intestinal barrier, antioxidant ability and protection against avian coccidiosis. A total of six hundred Cobb 500 was divided into six groups: first group (fed basal diet and unchallenged (control) and challenged (negative control, NC) groups were fed a basal diet without additives, and the other groups were infected with and supplemented with 1.
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